Enhanced Efficacy of Anti-D Immunoglobulin for Treating ITP is not Explained by Higher Immunoglobulin Polymer Content

Several reports have suggested that low dose anti-D immunoglobulin is superior to high dose immunoglobulin for treatment of idiopathic thrombocytopenia purpura (ITP). However, some findings suggest that it is not the anti-D activity per se that is responsible for efficacy for treatment of ITP with a...

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Bibliographic Details
Published in:Biologicals 2001-06, Vol.29 (2), p.75-79
Main Authors: Dolman, Carl, Thorpe, Susan J., Thorpe, Robin
Format: Article
Language:English
Subjects:
AFc receptors
Biopolymers - chemistry
D antigen
Dimerization
Drug Stability
Drug Storage
Humans
idiopathic thrombocytopenia purpura
immunoglobulins, anti-D, ITP, IgG polymers
Immunoglobulins, Intravenous - chemistry
Immunoglobulins, Intravenous - therapeutic use
Purpura, Thrombocytopenic, Idiopathic - immunology
Purpura, Thrombocytopenic, Idiopathic - therapy
Receptors, Fc - antagonists & inhibitors
Rho(D) Immune Globulin - chemistry
Rho(D) Immune Globulin - therapeutic use
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Summary:Several reports have suggested that low dose anti-D immunoglobulin is superior to high dose immunoglobulin for treatment of idiopathic thrombocytopenia purpura (ITP). However, some findings suggest that it is not the anti-D activity per se that is responsible for efficacy for treatment of ITP with anti-D immunoglobulin. Amongst alternative explanations for the mechanism of action is a relatively higher immunoglobulin polymer content of anti-D compared to other immunoglobulin products, which is more efficient in causing reticuloendothelial Fc receptor blockade. In order to investigate this we have evaluated the polymeric IgG content of anti-D and other immunoglobulin products. Different products showed considerable variation in immunoglobulin polymer content. There was no clear correlation between aggregate or dimer content and product type and anti-D as a class of product did not contain higher amounts of either dimer or aggregate compared to other products. Some manufacturers' products increased in polymer content on storage, but others did not show this effect. Therefore, higher immunoglobulin dimer and/or aggregate content cannot explain the increased efficacy of anti-D immunoglobulin for treatment of ITP. The role of polymeric Ig in efficacy for treatment of ITP is unclear.
ISSN:1045-1056
1095-8320
DOI:10.1006/biol.2001.0279