Incorporation of an Endogenous Neuromodulatory Lipid, Oleoylethanolamide, into Cubosomes: Nanostructural Characterization

Oleoylethanolamide (OEA) is an endogenous lipid with neuroprotective properties and the fortification of its concentration in the brain can be beneficial in the treatment of many neurodegenerative disorders. However, OEA is rapidly eliminated by hydrolysis in vivo, limiting its therapeutic potential...

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Bibliographic Details
Published in:Langmuir 2016-09, Vol.32 (35), p.8942-8950
Main Authors: Younus, Mohammad, Prentice, Richard N, Clarkson, Andrew N, Boyd, Ben J, Rizwan, Shakila B
Format: Article
Language:English
Subjects:
Drug Compounding
Drug Stability
Endocannabinoids - chemistry
Fatty Alcohols - chemistry
Interface Components: Nanops, Colloids, Emulsions, Surfactants, Proteins, Polymers
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Neuroprotective Agents - chemistry
Oleic Acids - chemistry
Particle Size
Poloxamer - chemistry
Polysorbates - chemistry
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Summary:Oleoylethanolamide (OEA) is an endogenous lipid with neuroprotective properties and the fortification of its concentration in the brain can be beneficial in the treatment of many neurodegenerative disorders. However, OEA is rapidly eliminated by hydrolysis in vivo, limiting its therapeutic potential. We hypothesize that packing OEA within a nanoparticulate system such as cubosomes, which can be used to target the blood–brain barrier (BBB), will protect it against hydrolysis and enable therapeutic concentrations to reach the brain. Cubosomes are lipid-based nanoparticles with a unique bicontinuous cubic phase internal structure. In the present study, the incorporation and chemical stability of OEA in cubosomes was investigated. Cubosomes containing OEA had a mean particle size of less than 200 nm with low polydispersity (polydispersity index
ISSN:0743-7463
1520-5827
DOI:10.1021/acs.langmuir.6b02395