Ratiometric analysis of in vivo retinal layer thicknesses in multiple sclerosis

We performed ratiometric analysis of retinal optical coherence tomography images for the first time in multiple sclerosis (MS) patients. The ratiometric analysis identified differences in several retinal layer thickness ratios in the cohort of MS subjects without a history of optic neuritis (ON) com...

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Bibliographic Details
Published in:Journal of biomedical optics 2016-09, Vol.21 (9), p.095001-095001
Main Authors: Bhaduri, Basanta, Nolan, Ryan M, Shelton, Ryan L, Pilutti, Lara A, Motl, Robert W, Boppart, Stephen A
Format: Article
Language:English
Subjects:
Adolescent
Adult
Female
Humans
Image Interpretation, Computer-Assisted - methods
Male
Middle Aged
Multiple Sclerosis - diagnostic imaging
Multiple Sclerosis - pathology
Research Papers: General
Retina - diagnostic imaging
Retina - pathology
Tomography, Optical Coherence - methods
Young Adult
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Summary:We performed ratiometric analysis of retinal optical coherence tomography images for the first time in multiple sclerosis (MS) patients. The ratiometric analysis identified differences in several retinal layer thickness ratios in the cohort of MS subjects without a history of optic neuritis (ON) compared to healthy control (HC) subjects, and there was no difference in standard retinal nerve fiber layer thickness (RNFLT). The difference in such ratios between HC subjects and those with mild MS-disability, without a difference in RNFLT, further suggests the possibility of using layer ratiometric analysis for detecting early retinal changes in MS. Ratiometric analysis may be useful and potentially more sensitive for detecting disease changes in MS.
ISSN:1083-3668
1560-2281
DOI:10.1117/1.JBO.21.9.095001