The histological significance of atypical glandular cells on cervical cytology: Experience at Groote Schuur Hospital, Cape Town, South Africa

Atypical glandular cells (AGC) identified on Pap tests may be markers for potentially significant pathology. Primarily, to correlate AGC findings at Groote Schuur Hospital (GSH, Cape Town, South Africa) with subsequent histological investigations and attempt to identify predictors of pathology relev...

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Bibliographic Details
Published in:South African medical journal 2016-09, Vol.106 (9), p.907-911
Main Authors: Hoffman, Lance D, Wu, Hue-Tsi
Format: Article
Language:English
Subjects:
Cancer
Carcinoma
Cervical cancer
Diagnosis
Papillomavirus infections
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Summary:Atypical glandular cells (AGC) identified on Pap tests may be markers for potentially significant pathology. Primarily, to correlate AGC findings at Groote Schuur Hospital (GSH, Cape Town, South Africa) with subsequent histological investigations and attempt to identify predictors of pathology relevant to the clinical management of women with a cytological diagnosis of AGC. Secondly, to compare the GSH data with data from similar international studies. Records of AGC Pap tests were retrieved from the laboratory database in the anatomical pathology laboratory at GSH and clinically relevant information was summarised based on the available information. Standard descriptive statistics were used to summarise the study data, and Fisher's exact test was used to compare categorical outcomes, where possible. Of the 237 women with a cytological diagnosis of AGC and who had subsequent histological diagnoses, 120 (50.6%) had significant pathology (cervical intraepithelial neoplasia (CIN) 2 or worse). Significant cervical pathology was most common in women aged
ISSN:0256-9574
DOI:10.7196/SAMJ.2016.v106i9.10472