An update on the epigenetics of glioblastomas

Glioblastomas, also known as glioblastoma multiforme (GBM), are the most aggressive and malignant type of primary brain tumor in adults, exhibiting notable variability at the histopathological, genetic and epigenetic levels. Recently, epigenetic alterations have emerged as a common hallmark of many...

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Bibliographic Details
Published in:Epigenomics 2016-09, Vol.8 (9), p.1289-1305
Main Authors: Ferreira, Wallax Augusto Silva, Pinheiro, Danilo do Rosário, Costa Junior, Carlos Antonio da, Rodrigues-Antunes, Symara, Araújo, Mariana Diniz, Leão Barros, Mariceli Baia, Teixeira, Adriana Corrêa de Souza, Faro, Thamirys Aline Silva, Burbano, Rommel Rodriguez, Oliveira, Edivaldo Herculano Correa de, Harada, Maria Lúcia, Borges, Bárbara do Nascimento
Format: Article
Language:English
Subjects:
Apoptosis
astrocytomas
biomarkers
Biomarkers, Tumor - genetics
Brain cancer
Brain Neoplasms - genetics
Brain Neoplasms - metabolism
Brain Neoplasms - pathology
Brain research
Brain tumors
cancer
Cancer therapies
Chemotherapy
Deoxyribonucleic acid
DNA
DNA methylation
DNA repair
Enzymes
Epigenesis, Genetic
epigenetic regulation
Epigenetics
Gene expression
Gene Expression Regulation, Neoplastic
genetic
Glioblastoma
Glioblastoma - genetics
Glioblastoma - metabolism
Glioblastoma - pathology
Glioma
gliomas
Humans
Medical prognosis
MicroRNAs
Mutation
Proteins
Radiation therapy
Stem cells
targeted therapy
Tumorigenesis
Tumors
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Summary:Glioblastomas, also known as glioblastoma multiforme (GBM), are the most aggressive and malignant type of primary brain tumor in adults, exhibiting notable variability at the histopathological, genetic and epigenetic levels. Recently, epigenetic alterations have emerged as a common hallmark of many tumors, including GBM. Considering that a deeper understanding of the epigenetic modifications that occur in GBM may increase the knowledge regarding the tumorigenesis, progression and recurrence of this disease, in this review we discuss the recent major advances in GBM epigenetics research involving histone modification, glioblastoma stem cells, DNA methylation, noncoding RNAs expression, including their main alterations and the use of epigenetic therapy as a valid option for GBM treatment.
ISSN:1750-1911
1750-192X
DOI:10.2217/epi-2016-0040