Clinical and morphological aspects of adenocarcinomas of the intestinal type in the inner nose: a retrospective multicenter analysis

• Published in: European archives of oto-rhino-laryngology 2016-10, Vol.273 (10), p.3207-3213
• Main Authors: Donhuijsen, K., Kollecker, I., Petersen, P., Gaßler, N., Wolf, J., Schroeder, H.-G.
• Format: Article
• Language: English
• Subjects: Adenocarcinoma - mortality; Adenocarcinoma - pathology; Adenocarcinoma - therapy; Adult; Aged; Aged, 80 and over; Dust; Female; Germany - epidemiology; Head and Neck Surgery; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Recurrence, Local - mortality; Neoplasm Recurrence, Local - pathology; Neurosurgery; Nose Neoplasms - mortality; Nose Neoplasms - pathology; Nose Neoplasms - therapy; Occupational Diseases - mortality; Occupational Exposure - adverse effects; Otorhinolaryngology; Paranasal Sinus Neoplasms - mortality; Paranasal Sinus Neoplasms - pathology; Paranasal Sinus Neoplasms - therapy; Prognosis; Radiotherapy, Adjuvant; Retrospective Studies; Rhinology; Wood - toxicity
• ISSN: 0937-4477; 1434-4726
• DOI: 10.1007/s00405-016-3987-4

Clinical and histological parameters from 117 patients with wood dust-related sinonasal adenocarcinomas of intestinal type (ITAC) were analyzed and correlated with a follow-up period of 5 years at least. The rate of survival for 5 years was 53.1 % and for 10 years 30.2 %. Only 33 patients were free of disease. 74.2 % of patients with recurrences died in relation to ITAC. As expected, tumors of T4-category had the worst prognosis. The mucus content of a tumor was the most important histological parameter. Endonasal methods of surgery had no more positive survival rates after 5 years. An effect of radiotherapy has to be in discussion. The high incidence of tumor recurrences requires control examinations consistently.