The Pharmacokinetics and Tissue Distribution of Honokiol and its Metabolites in Rats

Honokiol (HK) is the main bioactive compound isolated from the bark of Magnolia officinalis . The present work is the first to report the pharmacokinetics and distribution of HK and its two metabolites of hydroxylated HK conjugated with glucuronic and sulfuric acid (M1) and HK monoglucuronide (M2) i...

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Bibliographic Details
Published in:European journal of drug metabolism and pharmacokinetics 2016-10, Vol.41 (5), p.587-594
Main Authors: Jun-jun, Wang, Xiao-lei, Miao, Jing-ya, Chen, Yong, Chen
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Biphenyl Compounds - metabolism
Biphenyl Compounds - pharmacokinetics
Brain - metabolism
Glucuronic Acid - metabolism
Human Physiology
Kidney - metabolism
Lignans - metabolism
Lignans - pharmacokinetics
Liver - metabolism
Magnolia - chemistry
Male
Medical Biochemistry
Original Paper
Pharmaceutical Sciences/Technology
Pharmacology/Toxicology
Pharmacy
Plasma - metabolism
Rats
Rats, Wistar
Sulfuric Acids - metabolism
Tissue Distribution
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Summary:Honokiol (HK) is the main bioactive compound isolated from the bark of Magnolia officinalis . The present work is the first to report the pharmacokinetics and distribution of HK and its two metabolites of hydroxylated HK conjugated with glucuronic and sulfuric acid (M1) and HK monoglucuronide (M2) in plasma, liver, kidney and brain following oral administration of HK (40 mg/kg) to healthy Wistar rats. The results showed that only HK but not M1 or M2 was found in brain. Additionally, our work indicated that M2 not HK was the major compound in liver and plasma. The elimination of HK in liver, kidney and brain, and M2 in liver and kidney was more rapid than in plasma. The finding suggested that some of the pharmacological activity of HK might be generated by M2 but not HK.
ISSN:0378-7966
2107-0180
DOI:10.1007/s13318-015-0281-6