The Contributing Role of Bile Acids to Metabolic Improvements After Obesity and Metabolic Surgery

Obesity and metabolic surgery (OMS) leads to several metabolic improvements, which often occur prior to substantial weight loss. Therefore, other factors in addition to weight loss contribute to the metabolic benefits. This literature review offers an overview of studies investigating bile acids (BA...

Full description

Saved in:
Bibliographic Details
Published in:Obesity surgery 2016-10, Vol.26 (10), p.2492-2502
Main Authors: Fouladi, Farnaz, Mitchell, James E., Wonderlich, Joseph A., Steffen, Kristine J.
Format: Article
Language:English
Subjects:
Adaptation, Physiological - physiology
Bariatric Surgery
Bile Acids and Salts - biosynthesis
Bile Acids and Salts - metabolism
Enterohepatic Circulation - physiology
Gastrointestinal Microbiome - physiology
Gastrointestinal surgery
Homeostasis
Humans
Intestines - physiopathology
Medicine
Medicine & Public Health
Metabolism
Obesity
Obesity - physiopathology
Obesity - surgery
Obesity - therapy
Review Article
Surgery
Surgical outcomes
Surgical techniques
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Obesity and metabolic surgery (OMS) leads to several metabolic improvements, which often occur prior to substantial weight loss. Therefore, other factors in addition to weight loss contribute to the metabolic benefits. This literature review offers an overview of studies investigating bile acids (BAs) and their metabolic effects after OMS. Rearrangement of enterohepatic circulation, changes in BA synthesis, BA conjugation, intestinal reabsorption, and alterations in the gut microbiota are potential mechanisms for altered BA profiles after surgery. Increased BA levels are associated with improved glucose homeostasis and lipid profiles, which are mediated by two major receptors: the Transmembrane G-protein Coupled Receptor and the Farnesoid X Receptor. Therefore, pharmacological manipulation of BAs and their receptors may be viable targets for less invasive obesity treatment.
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-016-2272-3