Comparison of seroma production in breast conserving surgery with or without intraoperative radiotherapy as tumour bed boost

• Published in: Archives of gynecology and obstetrics 2016-10, Vol.294 (4), p.861-866
• Main Authors: Ebner, Florian, Schramm, Amelie, Bottke, Dirk, Friedl, Thomas WP, Wiegel, Thomas, Fink, Visnja, Lato, Kristian, Bekes, Inga, Janni, Wolfgang, de Gregorio, Nikolaus
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Breast - pathology; Breast cancer; Breast Neoplasms - complications; Breast Neoplasms - pathology; Breast Neoplasms - radiotherapy; Breast Neoplasms - surgery; Endocrinology; Female; Gynecologic Oncology; Gynecology; Human Genetics; Humans; Mastectomy - methods; Medicine; Medicine & Public Health; Middle Aged; Obstetrics/Perinatology/Midwifery; Radiation therapy; Retrospective Studies; Seroma - etiology; Surgery
• ISSN: 0932-0067; 1432-0711
• DOI: 10.1007/s00404-016-4124-8

Introduction One of the most common complications in breast conserving surgery is seroma formation. The origin of seroma formation remains unclear. While intraoperative radiotherapy (IORT) has been shown to be an alternative to whole breast irradiation, the influence on seroma production is unclear. Therefore, this analysis compares seroma production in patients with breast conserving surgery with or without IORT as tumour bed boost during breast conserving surgery. Method A retrospective analysis of seroma production in patients with nodal-negative (pN0sn) pT1/2 primary breast cancer treated between September 2010 and October 2013 at the Breast Cancer Centre, University Hospital Ulm was performed. Patients with neoadjuvant chemotherapy, previous breast/axillary surgery or more than one intervention were excluded. IORT was applied as a tumour bed boost with 50-kV X-rays (Intra beam ® ) delivering 9 Gy at the applicator surface. Seroma formation was measured using wound drains placed in breast and in axilla. Results Data of 152 patients (99 −IORT; 53 +IORT) were available for analysis. No significant differences between patients with or without IORT with regard to seroma production and number of days until drain removal were found (all p  > 0.05). Conclusion Patients with IORT encountered no increased seroma production and removal of the drains was not delayed compared to patients with breast conserving surgery only. Our results indicate that IORT does not increase the seroma production compared to surgery alone.