Effect of Bioregulators Isolated from Rat Liver and Blood Serum on the State of Murine Liver in Roller Organotypic Culture after CCl4-Induced Fibrosis

We studied the protective effect of bioregulators isolated from the liver and blood serum of mammals under conditions of manifest fibrosis. Fibrosis was induced by CCl 4 administration for 30 days and then, the liver was cultured in a roller organotypic culture for 30 days in the presence of bioregu...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016-08, Vol.161 (4), p.604-609
Main Authors: Nalobin, D. S., Krasnov, M. S., Alipkina, S. I., Syrchina, M. S., Yamskova, V. P., Yamskov, I. A.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Carbon Tetrachloride - toxicity
Cell Biology
Female
Internal Medicine
Laboratory Medicine
Liver - drug effects
Liver - metabolism
Liver Cirrhosis - blood
Liver Cirrhosis - chemically induced
Liver Cirrhosis - metabolism
Male
Mice
Organ Culture Techniques
Pathology
Rats
Rats, Wistar
Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
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Summary:We studied the protective effect of bioregulators isolated from the liver and blood serum of mammals under conditions of manifest fibrosis. Fibrosis was induced by CCl 4 administration for 30 days and then, the liver was cultured in a roller organotypic culture for 30 days in the presence of bioregulators. Hepatoprotective effect of bioregulators was evaluated on histological sections of the liver at different terms of culturing. Experiments with roller organotypic culture of the liver isolated from animals with in vivo CCl 4 -induced fibrosis demonstrated the protective effect of bioregulator of the liver origin, while bioregulator isolated from the blood was ineffective.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3468-1