Effect of Ti(+4) on in vitro bioactivity and antibacterial activity of silicate glass-ceramics

• Published in: Materials science & engineering. C, Materials for biological applications Materials for biological applications, 2016-12, Vol.69, p.1058-1067
• Main Authors: Riaz, Madeeha, Zia, Rehana, Saleemi, Farhat, Hussain, Tousif, Bashir, Farooq, Ikhram, Hafeez
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Calorimetry, Differential Scanning; Ceramics - chemistry; Compressive Strength; Silicon Dioxide - chemistry; Spectroscopy, Fourier Transform Infrared; Staphylococcus epidermidis - drug effects; Titanium - chemistry; X-Ray Diffraction
• ISSN: 1873-0191
• DOI: 10.1016/j.msec.2016.08.022

A novel glass-ceramic series in (48-x) SiO2-36 CaO-4 P2O5-12 Na2O-xTiO2 (where x=0, 3.5, 7, 10.5 and 14mol %) system was synthesized by crystallization of glass powders, obtained by melt quenching technique. The differential scanning calorimetric analysis (DSC) was used to study the non-isothermal crystallization kinetics of the as prepared glasses. The crystallization behaviour of glasses was analyzed under non-isothermal conditions, and qualitative phase analysis of glass-ceramics was made by X-ray diffraction. The in vitro bioactivity of synthesized glass-ceramics was studied in stimulated body fluid at 37°C under static condition for 24days. The formation of hydroxyl-carbonated apatite layer; evident of bioactivity of the material, was elucidated by XRD, FTIR, AAS, SEM and EDX analysis. The result showed that partial substitution of TiO2 with SiO2 negatively influenced bioactivity; it decreased with increase in concentration of TiO2. As Ti(+4) having stronger field strength as compared to Si(+4) so its replacement became the cause for reduction in degradation that in turn improved the chemical stability. The compressive strength was also enhanced with progress addition of TiO2 in the system. The antibacterial properties were examined against Staphylococcus Epidermidis. Strong antibacterial efficacy was observed with the addition of TiO2 in the system.