Toluene Alters Mu-Opioid Receptor Expression in the Rat Brainstem

Toluene is an ototoxic organic solvent widely used in industry and could be a cause of sleep apnea. Acute toluene administration in rats induces an increase in the number of neural cells immunostained for mu-opioid receptors in several brainstem nuclei, such as the inferior colliculus, dorsal and la...

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Bibliographic Details
Published in:Industrial Health 2001, Vol.39(3), pp.231-234
Main Authors: SARACIBAR, Gonzalo, HERNANDEZ, Maria Luisa, ECHEVARRIA, Enrique, BARBERO, Ismael, GUTIERREZ, Arantza, CASIS, Oscar
Format: Article
Language:English
Subjects:
Animals
Brain Stem - drug effects
Brain Stem - physiology
Infusions, Parenteral
Mu-opioid receptors
Rat brain
Rats
Receptors, Opioid, mu - biosynthesis
Receptors, Opioid, mu - drug effects
Sleep Apnea Syndromes - chemically induced
Toluene
Toluene - adverse effects
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Summary:Toluene is an ototoxic organic solvent widely used in industry and could be a cause of sleep apnea. Acute toluene administration in rats induces an increase in the number of neural cells immunostained for mu-opioid receptors in several brainstem nuclei, such as the inferior colliculus, dorsal and lateral periaqueductal gray and dorsal raphe, without changes in the superior colliculus and the interpeduncular and lateral reticular nuclei. These data suggest that mu-opioid receptors could be involved in toluene-induced neurotoxic effects on the physiological regulation of breathing during sleep, and auditive function.
ISSN:0019-8366
1880-8026
DOI:10.2486/indhealth.39.231