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Toluene Alters Mu-Opioid Receptor Expression in the Rat Brainstem

Toluene is an ototoxic organic solvent widely used in industry and could be a cause of sleep apnea. Acute toluene administration in rats induces an increase in the number of neural cells immunostained for mu-opioid receptors in several brainstem nuclei, such as the inferior colliculus, dorsal and la...

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Published in:	Industrial Health 2001, Vol.39(3), pp.231-234
Main Authors:	SARACIBAR, Gonzalo, HERNANDEZ, Maria Luisa, ECHEVARRIA, Enrique, BARBERO, Ismael, GUTIERREZ, Arantza, CASIS, Oscar
Format:	Article
Language:	English
Subjects:	Animals Brain Stem - drug effects Brain Stem - physiology Infusions, Parenteral Mu-opioid receptors Rat brain Rats Receptors, Opioid, mu - biosynthesis Receptors, Opioid, mu - drug effects Sleep Apnea Syndromes - chemically induced Toluene Toluene - adverse effects
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container_title	Industrial Health
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description	Toluene is an ototoxic organic solvent widely used in industry and could be a cause of sleep apnea. Acute toluene administration in rats induces an increase in the number of neural cells immunostained for mu-opioid receptors in several brainstem nuclei, such as the inferior colliculus, dorsal and lateral periaqueductal gray and dorsal raphe, without changes in the superior colliculus and the interpeduncular and lateral reticular nuclei. These data suggest that mu-opioid receptors could be involved in toluene-induced neurotoxic effects on the physiological regulation of breathing during sleep, and auditive function.
doi_str_mv	10.2486/indhealth.39.231
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subjects	Animals Brain Stem - drug effects Brain Stem - physiology Infusions, Parenteral Mu-opioid receptors Rat brain Rats Receptors, Opioid, mu - biosynthesis Receptors, Opioid, mu - drug effects Sleep Apnea Syndromes - chemically induced Toluene Toluene - adverse effects
title	Toluene Alters Mu-Opioid Receptor Expression in the Rat Brainstem
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