Cardiac Biomarkers in Systemic Sclerosis: Contribution of High‐Sensitivity Cardiac Troponin in Addition to N‐Terminal Pro‐Brain Natriuretic Peptide

• Published in: Arthritis care & research (2010) 2015-07, Vol.67 (7), p.1022-1030
• Main Authors: Avouac, Jérôme, Meune, Christophe, Chenevier‐Gobeaux, Camille, Borderie, Didier, Lefevre, Guillaume, Kahan, André, Allanore, Yannick
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers - blood; Cardiovascular Diseases - blood; Cardiovascular Diseases - diagnosis; Cardiovascular Diseases - epidemiology; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Natriuretic Peptide, Brain - blood; Peptide Fragments - blood; Risk Factors; Scleroderma, Systemic - blood; Scleroderma, Systemic - diagnosis; Scleroderma, Systemic - epidemiology; Troponin T - blood; Young Adult
• ISSN: 2151-464X; 2151-4658
• DOI: 10.1002/acr.22547

Objective To measure plasma concentrations of high‐sensitivity cardiac troponin T (HS‐cTnT) and N‐terminal pro–brain natriuretic peptide (NT‐proBNP) in patients with systemic sclerosis (SSc; scleroderma) and age‐ and sex‐matched healthy control subjects, and to examine the contribution of traditional cardiovascular risk factors and SSc features to the concentrations of these 2 cardiac biomarkers. Methods Plasma HS‐cTnT and NT‐proBNP concentrations were measured using the electrochemiluminescence method and sandwich immunoassay, respectively. Results The study group comprised 161 unrelated patients with SSc and 213 matched control subjects. HS‐cTnT and NT‐proBNP plasma levels were significantly increased in SSc patients compared with controls (both P 14 ng/liter. Increased NT‐proBNP concentrations were associated only with the presence of precapillary pulmonary hypertension (P