Pleural-based neuroblastoma-like schwannoma: A case report with cytologic findings and review of literature

We report a rare case of a 45‐year‐old African American woman with Neuroblastoma‐like Schwannoma (Neurilemmoma) occurring in the posterior mediastinum as a pleural‐based mass noted on computed tomography (CT) scan. A CT‐guided core biopsy of the mass was performed and core biopsy imprints were prepa...

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Bibliographic Details
Published in:Diagnostic cytopathology 2015-08, Vol.43 (8), p.650-653
Main Authors: Adams, Kristen, Liu, Xuehui Susan, Akhtar, Israh, Flowers, Rhyne, Baliga, Mithra
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - metabolism
core biopsy
cytology
Eosine Yellowish-(YS)
Female
Hematoxylin
Humans
Image-Guided Biopsy
Immunohistochemistry
mediastinum
Mediastinum - diagnostic imaging
Mediastinum - pathology
Mediastinum - surgery
Middle Aged
Neurilemmoma - diagnosis
Neurilemmoma - diagnostic imaging
Neurilemmoma - pathology
Neurilemmoma - surgery
neuroblastoma-like schwannoma
Pleural Neoplasms - diagnosis
Pleural Neoplasms - diagnostic imaging
Pleural Neoplasms - pathology
Pleural Neoplasms - surgery
S100 Proteins - metabolism
Tomography, X-Ray Computed
Vimentin - metabolism
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Summary:We report a rare case of a 45‐year‐old African American woman with Neuroblastoma‐like Schwannoma (Neurilemmoma) occurring in the posterior mediastinum as a pleural‐based mass noted on computed tomography (CT) scan. A CT‐guided core biopsy of the mass was performed and core biopsy imprints were prepared during the procedure. A Diff‐Quik stain was performed for on‐site evaluation of specimen adequacy. The hematoxylin and eosin (H&E) staining was evaluated subsequently. Immunohistochemistry panels were applied to the same specimen. The cytologic findings of the core biopsy imprints showed hypercellular smears with a predominance of small cells with atypical features including hyperchromatic, round nuclei and occasional nucleoli. Neurocytic rosettes were particularly appreciated on H&E stain. The immunohistochemical results exhibited strong and diffuse immunoreactivity for S‐100 and vimentin. This case enriches the cytopathology literature by providing awareness of this tumor presenting as a posterior mediastinal mass. Diagn. Cytopathol. 2015;43:650–653. © 2015 Wiley Periodicals, Inc.
ISSN:8755-1039
1097-0339
DOI:10.1002/dc.23293