The association between chronic obstructive pulmonary disease and Parkinson's disease: a nationwide population-based retrospective cohort study

Previous research has shown that patients with chronic obstructive pulmonary disease (COPD) tend to have a higher risk for cognitive impairment and dementia, a neurodegenerative disorder. The goal of this study was to examine what relationship, if any, exists between COPD and Parkinson's diseas...

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Bibliographic Details
Published in:QJM : An International Journal of Medicine 2015-01, Vol.108 (1), p.39-45
Main Authors: Li, C-H, Chen, W-C, Liao, W-C, Tu, C-Y, Lin, C-L, Sung, F-C, Chen, C-H, Hsu, W-H
Format: Article
Language:English
Subjects:
Age Distribution
Aged
Aged, 80 and over
Cohort Studies
Comorbidity
Female
Humans
Incidence
Male
Middle Aged
Parkinson Disease - epidemiology
Parkinson Disease - etiology
Pulmonary Disease, Chronic Obstructive - complications
Pulmonary Disease, Chronic Obstructive - epidemiology
Retrospective Studies
Sex Distribution
Taiwan - epidemiology
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Summary:Previous research has shown that patients with chronic obstructive pulmonary disease (COPD) tend to have a higher risk for cognitive impairment and dementia, a neurodegenerative disorder. The goal of this study was to examine what relationship, if any, exists between COPD and Parkinson's disease (PD), which is also a neurodegenerative disorder. Our study analyzed medical data from the population of Taiwan from 1998 to 2008, with a follow-up period extending to the end of 2010. We identified patients with COPD by the Taiwan National Health Insurance Research Database (NHIRD). We selected a comparison cohort from the general population that was random frequency-matched by age (in 5-year increments), sex and index year, and further analyzed the risk of PD using Cox's regression model, including sex, age and comorbidities. The study enrolled 20 728 COPD patients (71.1% male, mean age = 68.2 years) and 41 147 controls. The risk of developing PD was 1.37 times greater in patients with COPD compared with patients without COPD after adjusting for age, sex and comorbidities. A significantly increased risk of PD was also found in patients with COPD who had any comorbidity other than diabetes. This nationwide retrospective cohort study demonstrates that PD risk is significantly increased in patients with COPD compared with those of the general population.
ISSN:1460-2725
1460-2393
DOI:10.1093/qjmed/hcu136