Evaluation of white matter integrity in systemic lupus erythematosus by diffusion tensor magnetic resonance imaging: a study using tract-based spatial statistics

Introduction The aim of this study was to evaluate the white matter integrity in brains of patients with systemic lupus erythematosus (SLE) using a voxel-based analyses of diffusion tensor imaging (DTI) data. Methods Fifty-seven patients with SLE were compared to 36 control patients who were matched...

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Bibliographic Details
Published in:Neuroradiology 2016-08, Vol.58 (8), p.819-825
Main Authors: Corrêa, Diogo Goulart, Zimmermann, Nicolle, Pereira, Denis Batista, Doring, Thomas M., Netto, Tania Maria, Ventura, Nina, Fonseca, Rochele Paz, Gasparetto, Emerson Leandro
Format: Article
Language:English
Subjects:
Adult
Brain - diagnostic imaging
Brain - pathology
Brain research
Computer Simulation
Diffusion
Diffusion Tensor Imaging - methods
Female
Functional Neuroradiology
Humans
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Imaging
Lupus
Lupus Vasculitis, Central Nervous System - diagnostic imaging
Lupus Vasculitis, Central Nervous System - pathology
Male
Medicine
Medicine & Public Health
Models, Statistical
Neurology
Neuroradiology
Neurosciences
Neurosurgery
NMR
Nuclear magnetic resonance
Radiology
Reproducibility of Results
Sensitivity and Specificity
White Matter - diagnostic imaging
White Matter - pathology
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Summary:Introduction The aim of this study was to evaluate the white matter integrity in brains of patients with systemic lupus erythematosus (SLE) using a voxel-based analyses of diffusion tensor imaging (DTI) data. Methods Fifty-seven patients with SLE were compared to 36 control patients who were matched by gender, age, education, and Mini Mental State Examination score. DTI was performed along 30 noncollinear directions in a 1.5 Tesla scanner. For tract-based spatial statistics (TBSS), a white matter skeleton was created, and a permutation-based inference with 5000 permutations and a threshold of p  
ISSN:0028-3940
1432-1920
DOI:10.1007/s00234-016-1688-8