Low 24-hour urine calcium levels in patients with sporadic primary hyperparathyroidism: is further evaluation warranted prior to parathyroidectomy?

Abstract Background Low 24-hour urine calcium (uCa) levels in patients with primary hyperparathyroidism (pHPT) raise concern for familial hypocalciuric hypercalcemia. This study evaluated patients with a low 24-hour uCa level for potential differences that may guide the extent of preoperative evalua...

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Bibliographic Details
Published in:The American journal of surgery 2015-07, Vol.210 (1), p.123-128
Main Authors: O'Connell, Kathleen, M.D, Yen, Tina W., M.D, Shaker, Joseph, M.D, Wilson, Stuart D., M.D, Evans, Douglas B., M.D, Wang, Tracy S., M.D., M.P.H
Format: Article
Language:English
Subjects:
24-Hour urine calcium
Adapter proteins
Adult
Aged
Aged, 80 and over
Calcium
Calcium - urine
Circadian Rhythm
Disease
Diuretics
Familial hypocalciuric hypercalcemia
Families & family life
Family medical history
Female
Humans
Hyperparathyroidism, Primary - surgery
Hyperparathyroidism, Primary - urine
Laboratories
Male
Middle Aged
Mutation
Parathyroidectomy
Patients
Preoperative Care
Primary hyperparathyroidism
Retrospective Studies
Surgery
Time Factors
Tomography
Urine
Vitamin D
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Summary:Abstract Background Low 24-hour urine calcium (uCa) levels in patients with primary hyperparathyroidism (pHPT) raise concern for familial hypocalciuric hypercalcemia. This study evaluated patients with a low 24-hour uCa level for potential differences that may guide the extent of preoperative evaluation needed. Methods A retrospective review was conducted of 1,139 sporadic pHPT patients who underwent parathyroidectomy between December 1999 and May 2011. Results Of the 54 (5%) patients with greater than or equal to one low 24-hour uCa (
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2014.09.030