Enantioselective sulfoxidation reaction catalyzed by a G-quadruplex DNA metalloenzyme

Enantioselective sulfoxidation reaction is achieved for the first time by a DNA metalloenzyme assembled with the human telomeric G-quadruplex DNA and Cu( ii )-4,4′-bimethyl-2,2′-bipyridine complex, and the mixed G-quadruplex architectures are responsible for the catalytic enantioselectivity and acti...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2016-07, Vol.52 (62), p.9644-9647
Main Authors: Cheng, Mingpan, Li, Yinghao, Zhou, Jun, Jia, Guoqing, Lu, Sheng-Mei, Yang, Yan, Li, Can
Format: Article
Language:English
Subjects:
Architecture
Biocatalysis
Catalysis
Catalysts
Chemical reactions
Deoxyribonucleic acid
G-Quadruplexes
Human behavior
Humans
Metalloproteins - chemistry
Metalloproteins - metabolism
Molecular Structure
Stereoisomerism
Sulfoxides - chemistry
Sulfoxides - metabolism
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Summary:Enantioselective sulfoxidation reaction is achieved for the first time by a DNA metalloenzyme assembled with the human telomeric G-quadruplex DNA and Cu( ii )-4,4′-bimethyl-2,2′-bipyridine complex, and the mixed G-quadruplex architectures are responsible for the catalytic enantioselectivity and activity. Enantioselective sulfoxidation reaction is achieved for the first time by a human telomeric G-quadruplex DNA based biocatalyst.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc03016e