Copper-influenced changes in lactate dehydrogenase and G-6-PDH activities of the freshwater teleost, Labeo rohita

Labeo rohita were exposed to acute and subacute concentrations of copper, and effects on lactate dehydrogenase and glucose 6-phosphate dehydrogenase (G-6-PDH) activities in gill, liver, brain, and muscle were examined. Upon exposure to a lethal concentration, lactate dehydrogenase and G-6-PDH activi...

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Bibliographic Details
Published in:Bulletin of environmental contamination and toxicology 2001-08, Vol.67 (2), p.257-263
Main Authors: VENKATARAMANA, P, RADHAKRISHNAIAH, K
Format: Article
Language:English
Subjects:
Agnatha. Pisces
Animal, plant and microbial ecology
Animals
Applied ecology
Biological and medical sciences
Brain - drug effects
Brain - enzymology
Copper - pharmacokinetics
Copper - toxicity
Ecotoxicology, biological effects of pollution
Effects of pollution and side effects of pesticides on vertebrates
Fishes
Fresh Water
Fundamental and applied biological sciences. Psychology
Gills - drug effects
Gills - enzymology
Guanosine Diphosphate - metabolism
L-Lactate Dehydrogenase - metabolism
Labeo rohita
Lethal Dose 50
Liver - drug effects
Liver - enzymology
Tissue Distribution
Water Pollutants, Chemical - pharmacokinetics
Water Pollutants, Chemical - toxicity
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Summary:Labeo rohita were exposed to acute and subacute concentrations of copper, and effects on lactate dehydrogenase and glucose 6-phosphate dehydrogenase (G-6-PDH) activities in gill, liver, brain, and muscle were examined. Upon exposure to a lethal concentration, lactate dehydrogenase and G-6-PDH activities were increased and decreased, respectively, significantly in all tissues examined. Behavioral changes were also observed, such as irritability, irregular erratic swimming and jumping, restlessness, coagulated mucus film covering over gill epithelium, shrinkage in epithelium, and color changes. At sublethal Cu concentrations, lactate dehydrogenase activity was increased less dramatically, and G-6-PDH activity was increased. As sublethal exposure duration increased, enzyme activities recovered to near-normal states, indicating the activation of metal detoxification and elimination pathways.
ISSN:0007-4861
1432-0800
DOI:10.1007/s001280118