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Copper-influenced changes in lactate dehydrogenase and G-6-PDH activities of the freshwater teleost, Labeo rohita
Labeo rohita were exposed to acute and subacute concentrations of copper, and effects on lactate dehydrogenase and glucose 6-phosphate dehydrogenase (G-6-PDH) activities in gill, liver, brain, and muscle were examined. Upon exposure to a lethal concentration, lactate dehydrogenase and G-6-PDH activi...
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| Published in: | Bulletin of environmental contamination and toxicology 2001-08, Vol.67 (2), p.257-263 |
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| container_end_page | 263 |
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| container_title | Bulletin of environmental contamination and toxicology |
| container_volume | 67 |
| creator | VENKATARAMANA, P RADHAKRISHNAIAH, K |
| description | Labeo rohita were exposed to acute and subacute concentrations of copper, and effects on lactate dehydrogenase and glucose 6-phosphate dehydrogenase (G-6-PDH) activities in gill, liver, brain, and muscle were examined. Upon exposure to a lethal concentration, lactate dehydrogenase and G-6-PDH activities were increased and decreased, respectively, significantly in all tissues examined. Behavioral changes were also observed, such as irritability, irregular erratic swimming and jumping, restlessness, coagulated mucus film covering over gill epithelium, shrinkage in epithelium, and color changes. At sublethal Cu concentrations, lactate dehydrogenase activity was increased less dramatically, and G-6-PDH activity was increased. As sublethal exposure duration increased, enzyme activities recovered to near-normal states, indicating the activation of metal detoxification and elimination pathways. |
| doi_str_mv | 10.1007/s001280118 |
| format | article |
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Upon exposure to a lethal concentration, lactate dehydrogenase and G-6-PDH activities were increased and decreased, respectively, significantly in all tissues examined. Behavioral changes were also observed, such as irritability, irregular erratic swimming and jumping, restlessness, coagulated mucus film covering over gill epithelium, shrinkage in epithelium, and color changes. At sublethal Cu concentrations, lactate dehydrogenase activity was increased less dramatically, and G-6-PDH activity was increased. As sublethal exposure duration increased, enzyme activities recovered to near-normal states, indicating the activation of metal detoxification and elimination pathways.</description><identifier>ISSN: 0007-4861</identifier><identifier>EISSN: 1432-0800</identifier><identifier>DOI: 10.1007/s001280118</identifier><identifier>PMID: 11429684</identifier><identifier>CODEN: BECTA6</identifier><language>eng</language><publisher>New York, NY: Springer-Verlag</publisher><subject>Agnatha. 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Psychology ; Gills - drug effects ; Gills - enzymology ; Guanosine Diphosphate - metabolism ; L-Lactate Dehydrogenase - metabolism ; Labeo rohita ; Lethal Dose 50 ; Liver - drug effects ; Liver - enzymology ; Tissue Distribution ; Water Pollutants, Chemical - pharmacokinetics ; Water Pollutants, Chemical - toxicity</subject><ispartof>Bulletin of environmental contamination and toxicology, 2001-08, Vol.67 (2), p.257-263</ispartof><rights>2002 INIST-CNRS</rights><rights>Bulletin of Environmental Contamination and Toxicology is a copyright of Springer, 2001.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14109587$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11429684$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VENKATARAMANA, P</creatorcontrib><creatorcontrib>RADHAKRISHNAIAH, K</creatorcontrib><title>Copper-influenced changes in lactate dehydrogenase and G-6-PDH activities of the freshwater teleost, Labeo rohita</title><title>Bulletin of environmental contamination and toxicology</title><addtitle>Bull Environ Contam Toxicol</addtitle><description>Labeo rohita were exposed to acute and subacute concentrations of copper, and effects on lactate dehydrogenase and glucose 6-phosphate dehydrogenase (G-6-PDH) activities in gill, liver, brain, and muscle were examined. Upon exposure to a lethal concentration, lactate dehydrogenase and G-6-PDH activities were increased and decreased, respectively, significantly in all tissues examined. Behavioral changes were also observed, such as irritability, irregular erratic swimming and jumping, restlessness, coagulated mucus film covering over gill epithelium, shrinkage in epithelium, and color changes. At sublethal Cu concentrations, lactate dehydrogenase activity was increased less dramatically, and G-6-PDH activity was increased. As sublethal exposure duration increased, enzyme activities recovered to near-normal states, indicating the activation of metal detoxification and elimination pathways.</description><subject>Agnatha. Pisces</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - enzymology</subject><subject>Copper - pharmacokinetics</subject><subject>Copper - toxicity</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Effects of pollution and side effects of pesticides on vertebrates</subject><subject>Fishes</subject><subject>Fresh Water</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>Gills - drug effects</topic><topic>Gills - enzymology</topic><topic>Guanosine Diphosphate - metabolism</topic><topic>L-Lactate Dehydrogenase - metabolism</topic><topic>Labeo rohita</topic><topic>Lethal Dose 50</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Tissue Distribution</topic><topic>Water Pollutants, Chemical - pharmacokinetics</topic><topic>Water Pollutants, Chemical - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VENKATARAMANA, P</creatorcontrib><creatorcontrib>RADHAKRISHNAIAH, K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Environment Abstracts</collection><collection>Environment Abstracts</collection><collection>Aqualine</collection><collection>Water Resources Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Bulletin of environmental contamination and toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VENKATARAMANA, P</au><au>RADHAKRISHNAIAH, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Copper-influenced changes in lactate dehydrogenase and G-6-PDH activities of the freshwater teleost, Labeo rohita</atitle><jtitle>Bulletin of environmental contamination and toxicology</jtitle><addtitle>Bull Environ Contam Toxicol</addtitle><date>2001-08-01</date><risdate>2001</risdate><volume>67</volume><issue>2</issue><spage>257</spage><epage>263</epage><pages>257-263</pages><issn>0007-4861</issn><eissn>1432-0800</eissn><coden>BECTA6</coden><abstract>Labeo rohita were exposed to acute and subacute concentrations of copper, and effects on lactate dehydrogenase and glucose 6-phosphate dehydrogenase (G-6-PDH) activities in gill, liver, brain, and muscle were examined. Upon exposure to a lethal concentration, lactate dehydrogenase and G-6-PDH activities were increased and decreased, respectively, significantly in all tissues examined. Behavioral changes were also observed, such as irritability, irregular erratic swimming and jumping, restlessness, coagulated mucus film covering over gill epithelium, shrinkage in epithelium, and color changes. At sublethal Cu concentrations, lactate dehydrogenase activity was increased less dramatically, and G-6-PDH activity was increased. As sublethal exposure duration increased, enzyme activities recovered to near-normal states, indicating the activation of metal detoxification and elimination pathways.</abstract><cop>New York, NY</cop><pub>Springer-Verlag</pub><pmid>11429684</pmid><doi>10.1007/s001280118</doi><tpages>7</tpages></addata></record> |
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| subjects | Agnatha. Pisces Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences Brain - drug effects Brain - enzymology Copper - pharmacokinetics Copper - toxicity Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates Fishes Fresh Water Fundamental and applied biological sciences. Psychology Gills - drug effects Gills - enzymology Guanosine Diphosphate - metabolism L-Lactate Dehydrogenase - metabolism Labeo rohita Lethal Dose 50 Liver - drug effects Liver - enzymology Tissue Distribution Water Pollutants, Chemical - pharmacokinetics Water Pollutants, Chemical - toxicity |
| title | Copper-influenced changes in lactate dehydrogenase and G-6-PDH activities of the freshwater teleost, Labeo rohita |
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