Metabolic reprogramming of myeloid-derived suppressor cells (MDSC) in cancer

MDSC undergo metabolic reprogramming in the tumor resulting in an increased fatty acid β oxidation that supports their immunosuppressive functions. Fatty acid oxidation inhibitors, used to treat coronary disease, significantly delayed tumor growth and had a significantly increased antitumor effect w...

Full description

Saved in:
Bibliographic Details
Published in:Oncoimmunology 2016-08, Vol.5 (8), p.e1200771-e1200771
Main Authors: Al-Khami, Amir A., Rodriguez, Paulo C., Ochoa, Augusto C.
Format: Article
Language:English
Subjects:
Author's View
Cancer
Immunometabolism
MDSC
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:MDSC undergo metabolic reprogramming in the tumor resulting in an increased fatty acid β oxidation that supports their immunosuppressive functions. Fatty acid oxidation inhibitors, used to treat coronary disease, significantly delayed tumor growth and had a significantly increased antitumor effect when combined with adoptive cell therapy or low dose chemotherapy.
ISSN:2162-4011
2162-402X
2162-402X
DOI:10.1080/2162402X.2016.1200771