Modulation of virulence in Acinetobacter baumannii cells surviving photodynamic treatment with toluidine blue

Highlights • In the sublethal TBO concentration and sublethal LED-treated samples; there was a statistically non-significant reduction in csuE , epsA and abaI mRNA expressions. • Sublethal PDT would lead to modulation of the virulence of A. baumannii strains in surviving cells in planktonic growth m...

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Bibliographic Details
Published in:Photodiagnosis and photodynamic therapy 2016-09, Vol.15, p.202-212
Main Authors: Pourhajibagher, Maryam, Boluki, Ebrahim, Chiniforush, Nasim, Pourakbari, Babak, Farshadzadeh, Zahra, Ghorbanzadeh, R, Aziemzadeh, Masoud, Bahador, Abbas
Format: Article
Language:English
Subjects:
Acinetobacter baumannii
Acinetobacter baumannii - drug effects
Acinetobacter baumannii - pathogenicity
Acinetobacter baumannii - radiation effects
Antimicrobial resistance
Cell Survival - drug effects
Cell Survival - physiology
Cell Survival - radiation effects
Disinfection - methods
Dose-Response Relationship, Drug
Dose-Response Relationship, Radiation
Drug Therapy, Combination - methods
Hematology, Oncology and Palliative Medicine
Humans
Internal Medicine
Photochemotherapy - methods
Photodynamic therapy
Photosensitizing Agents - administration & dosage
Sublethal
Tolonium Chloride - administration & dosage
Virulence - drug effects
Virulence - physiology
Virulence genes
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Summary:Highlights • In the sublethal TBO concentration and sublethal LED-treated samples; there was a statistically non-significant reduction in csuE , epsA and abaI mRNA expressions. • Sublethal PDT would lead to modulation of the virulence of A. baumannii strains in surviving cells in planktonic growth mode by suppressing the expression of the genes associated with biofilm formation, except blsA at the transcriptional level. • Irradiation of CR-XDR-AB strain in surviving cells with sublethal PDT resulted in reduction of cell metabolic activity, increase in outer membrane permeability, and inhibition of efflux pump systems.
ISSN:1572-1000
1873-1597
DOI:10.1016/j.pdpdt.2016.07.007