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Mindfulness-based cognitive therapy for youth with anxiety disorders at risk for bipolar disorder: a pilot trial

Aim Children and adolescents with bipolar parents have an elevated risk for anxiety disorders. However, antidepressant medications commonly used to treat symptoms of anxiety may accelerate the onset of mania in these already at‐risk youth. Therefore, studies evaluating innovative non‐pharmacologic t...

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Published in:Early intervention in psychiatry 2016-10, Vol.10 (5), p.426-434
Main Authors: Cotton, Sian, Luberto, Christina M., Sears, Richard W., Strawn, Jeffrey R., Stahl, Lauren, Wasson, Rachel S., Blom, Thomas J., Delbello, Melissa P.
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cited_by cdi_FETCH-LOGICAL-c4616-a9334af83961ee714bcdffee485b9806f70906a2695eb3fe9481e30729836723
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container_end_page 434
container_issue 5
container_start_page 426
container_title Early intervention in psychiatry
container_volume 10
creator Cotton, Sian
Luberto, Christina M.
Sears, Richard W.
Strawn, Jeffrey R.
Stahl, Lauren
Wasson, Rachel S.
Blom, Thomas J.
Delbello, Melissa P.
description Aim Children and adolescents with bipolar parents have an elevated risk for anxiety disorders. However, antidepressant medications commonly used to treat symptoms of anxiety may accelerate the onset of mania in these already at‐risk youth. Therefore, studies evaluating innovative non‐pharmacologic treatments for anxiety in this population are urgently needed. Methods Subjects participated in 12 weekly sessions of mindfulness‐based cognitive therapy for children (MBCT‐C), a manualized group psychotherapeutic intervention utilizing cognitive behavioural principles and mindfulness exercises to increase regulation of attention and non‐judgmental acceptance of present moment thoughts, emotions and experiences. Independent raters administered symptoms rating scales prior to each treatment session. Spearman correlations and paired‐samples signed rank tests were used to examine outcomes. After‐intervention surveys and session transcripts were reviewed to assess feasibility and acceptability of the intervention. Results Participants included 10 youth (meanage = 13.2; 80% girls; 40% biracial) with generalized, social and/or separation anxiety disorders, and a parent with bipolar disorder. Clinician‐rated anxiety was significantly reduced after intervention (meanbefore = 11.1; meanafter = 4.3; P 
doi_str_mv 10.1111/eip.12216
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However, antidepressant medications commonly used to treat symptoms of anxiety may accelerate the onset of mania in these already at‐risk youth. Therefore, studies evaluating innovative non‐pharmacologic treatments for anxiety in this population are urgently needed. Methods Subjects participated in 12 weekly sessions of mindfulness‐based cognitive therapy for children (MBCT‐C), a manualized group psychotherapeutic intervention utilizing cognitive behavioural principles and mindfulness exercises to increase regulation of attention and non‐judgmental acceptance of present moment thoughts, emotions and experiences. Independent raters administered symptoms rating scales prior to each treatment session. Spearman correlations and paired‐samples signed rank tests were used to examine outcomes. After‐intervention surveys and session transcripts were reviewed to assess feasibility and acceptability of the intervention. Results Participants included 10 youth (meanage = 13.2; 80% girls; 40% biracial) with generalized, social and/or separation anxiety disorders, and a parent with bipolar disorder. Clinician‐rated anxiety was significantly reduced after intervention (meanbefore = 11.1; meanafter = 4.3; P &lt; 0.01), as well as youth‐rated trait anxiety (P = 0.03). Parent‐rated emotion regulation significantly increased from before to after intervention (P = 0.05). Increases in mindfulness were associated with decreases in anxiety (P = 0.03). Finally, children and parents/guardians reported high levels of feasibility, acceptability and usefulness of the intervention. Conclusion Findings support the feasibility, acceptability and preliminary efficacy of MBCT‐C for treating anxiety in youth at risk for bipolar disorder. Future controlled and larger studies are needed to confirm these preliminary findings.</description><identifier>ISSN: 1751-7885</identifier><identifier>EISSN: 1751-7893</identifier><identifier>DOI: 10.1111/eip.12216</identifier><identifier>PMID: 25582800</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Anxiety ; Anxiety Disorders - therapy ; bipolar ; Bipolar disorder ; Bipolar Disorder - psychology ; Child ; Children &amp; youth ; Cognitive therapy ; Cognitive Therapy - methods ; Female ; Humans ; Male ; MBCT-C ; Mindfulness ; Parents - psychology ; Pilot Projects ; Psychotherapy, Group ; youth</subject><ispartof>Early intervention in psychiatry, 2016-10, Vol.10 (5), p.426-434</ispartof><rights>2015 Wiley Publishing Asia Pty Ltd</rights><rights>2015 Wiley Publishing Asia Pty Ltd.</rights><rights>2016 John Wiley &amp; Sons Australia, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4616-a9334af83961ee714bcdffee485b9806f70906a2695eb3fe9481e30729836723</citedby><cites>FETCH-LOGICAL-c4616-a9334af83961ee714bcdffee485b9806f70906a2695eb3fe9481e30729836723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25582800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cotton, Sian</creatorcontrib><creatorcontrib>Luberto, Christina M.</creatorcontrib><creatorcontrib>Sears, Richard W.</creatorcontrib><creatorcontrib>Strawn, Jeffrey R.</creatorcontrib><creatorcontrib>Stahl, Lauren</creatorcontrib><creatorcontrib>Wasson, Rachel S.</creatorcontrib><creatorcontrib>Blom, Thomas J.</creatorcontrib><creatorcontrib>Delbello, Melissa P.</creatorcontrib><title>Mindfulness-based cognitive therapy for youth with anxiety disorders at risk for bipolar disorder: a pilot trial</title><title>Early intervention in psychiatry</title><addtitle>Early Intervention in Psychiatry</addtitle><description>Aim Children and adolescents with bipolar parents have an elevated risk for anxiety disorders. However, antidepressant medications commonly used to treat symptoms of anxiety may accelerate the onset of mania in these already at‐risk youth. Therefore, studies evaluating innovative non‐pharmacologic treatments for anxiety in this population are urgently needed. Methods Subjects participated in 12 weekly sessions of mindfulness‐based cognitive therapy for children (MBCT‐C), a manualized group psychotherapeutic intervention utilizing cognitive behavioural principles and mindfulness exercises to increase regulation of attention and non‐judgmental acceptance of present moment thoughts, emotions and experiences. Independent raters administered symptoms rating scales prior to each treatment session. Spearman correlations and paired‐samples signed rank tests were used to examine outcomes. After‐intervention surveys and session transcripts were reviewed to assess feasibility and acceptability of the intervention. Results Participants included 10 youth (meanage = 13.2; 80% girls; 40% biracial) with generalized, social and/or separation anxiety disorders, and a parent with bipolar disorder. Clinician‐rated anxiety was significantly reduced after intervention (meanbefore = 11.1; meanafter = 4.3; P &lt; 0.01), as well as youth‐rated trait anxiety (P = 0.03). Parent‐rated emotion regulation significantly increased from before to after intervention (P = 0.05). Increases in mindfulness were associated with decreases in anxiety (P = 0.03). Finally, children and parents/guardians reported high levels of feasibility, acceptability and usefulness of the intervention. Conclusion Findings support the feasibility, acceptability and preliminary efficacy of MBCT‐C for treating anxiety in youth at risk for bipolar disorder. Future controlled and larger studies are needed to confirm these preliminary findings.</description><subject>Adolescent</subject><subject>Anxiety</subject><subject>Anxiety Disorders - therapy</subject><subject>bipolar</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - psychology</subject><subject>Child</subject><subject>Children &amp; youth</subject><subject>Cognitive therapy</subject><subject>Cognitive Therapy - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>MBCT-C</subject><subject>Mindfulness</subject><subject>Parents - psychology</subject><subject>Pilot Projects</subject><subject>Psychotherapy, Group</subject><subject>youth</subject><issn>1751-7885</issn><issn>1751-7893</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp10UtPFTEUB_DGaOShC7-AaeJGFgN9zPThDgkgEdAEEpdNZ-ZUCnOnY9sR5ttbuXAXJnbRNunv_HPSg9A7SvZpWQfgp33KGBUv0DaVDa2k0vzl5q6aLbST0i0hjRSMvkZbrGkUU4Rso-nCj72bhxFSqlqboMdd-Dn67H8DzjcQ7bRgFyJewpxv8L0vmx0fPOQF9z6F2ENM2GYcfbp7hK2fwmDj5vUTtnjyQ8g4R2-HN-iVs0OCt0_nLro-Ob4--lKdfzs9Ozo8r7paUFFZzXltneJaUABJ67brnQOoVdNqRYSTRBNhmdANtNyBrhUFTiTTigvJ-C76uI6dYvg1Q8pm5VMHw2BHCHMyVDHS6JpIVeiHf-htmONYmiuKak4Z0XVRe2vVxZBSBGem6Fc2LoYS83cKpkzBPE6h2PdPiXO7gn4jn7-9gIM1uPcDLP9PMsdn358jq3WFTxkeNhU23hkhuWzMj8tTcyVPLi6_6ivzmf8B2XagWQ</recordid><startdate>201610</startdate><enddate>201610</enddate><creator>Cotton, Sian</creator><creator>Luberto, Christina M.</creator><creator>Sears, Richard W.</creator><creator>Strawn, Jeffrey R.</creator><creator>Stahl, Lauren</creator><creator>Wasson, Rachel S.</creator><creator>Blom, Thomas J.</creator><creator>Delbello, Melissa P.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201610</creationdate><title>Mindfulness-based cognitive therapy for youth with anxiety disorders at risk for bipolar disorder: a pilot trial</title><author>Cotton, Sian ; 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Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Early intervention in psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cotton, Sian</au><au>Luberto, Christina M.</au><au>Sears, Richard W.</au><au>Strawn, Jeffrey R.</au><au>Stahl, Lauren</au><au>Wasson, Rachel S.</au><au>Blom, Thomas J.</au><au>Delbello, Melissa P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mindfulness-based cognitive therapy for youth with anxiety disorders at risk for bipolar disorder: a pilot trial</atitle><jtitle>Early intervention in psychiatry</jtitle><addtitle>Early Intervention in Psychiatry</addtitle><date>2016-10</date><risdate>2016</risdate><volume>10</volume><issue>5</issue><spage>426</spage><epage>434</epage><pages>426-434</pages><issn>1751-7885</issn><eissn>1751-7893</eissn><abstract>Aim Children and adolescents with bipolar parents have an elevated risk for anxiety disorders. However, antidepressant medications commonly used to treat symptoms of anxiety may accelerate the onset of mania in these already at‐risk youth. Therefore, studies evaluating innovative non‐pharmacologic treatments for anxiety in this population are urgently needed. Methods Subjects participated in 12 weekly sessions of mindfulness‐based cognitive therapy for children (MBCT‐C), a manualized group psychotherapeutic intervention utilizing cognitive behavioural principles and mindfulness exercises to increase regulation of attention and non‐judgmental acceptance of present moment thoughts, emotions and experiences. Independent raters administered symptoms rating scales prior to each treatment session. Spearman correlations and paired‐samples signed rank tests were used to examine outcomes. After‐intervention surveys and session transcripts were reviewed to assess feasibility and acceptability of the intervention. Results Participants included 10 youth (meanage = 13.2; 80% girls; 40% biracial) with generalized, social and/or separation anxiety disorders, and a parent with bipolar disorder. Clinician‐rated anxiety was significantly reduced after intervention (meanbefore = 11.1; meanafter = 4.3; P &lt; 0.01), as well as youth‐rated trait anxiety (P = 0.03). Parent‐rated emotion regulation significantly increased from before to after intervention (P = 0.05). Increases in mindfulness were associated with decreases in anxiety (P = 0.03). Finally, children and parents/guardians reported high levels of feasibility, acceptability and usefulness of the intervention. Conclusion Findings support the feasibility, acceptability and preliminary efficacy of MBCT‐C for treating anxiety in youth at risk for bipolar disorder. Future controlled and larger studies are needed to confirm these preliminary findings.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>25582800</pmid><doi>10.1111/eip.12216</doi><tpages>9</tpages></addata></record>
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subjects Adolescent
Anxiety
Anxiety Disorders - therapy
bipolar
Bipolar disorder
Bipolar Disorder - psychology
Child
Children & youth
Cognitive therapy
Cognitive Therapy - methods
Female
Humans
Male
MBCT-C
Mindfulness
Parents - psychology
Pilot Projects
Psychotherapy, Group
youth
title Mindfulness-based cognitive therapy for youth with anxiety disorders at risk for bipolar disorder: a pilot trial
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