Metabolic flexibility and oxidative capacity independently associate with insulin sensitivity in individuals with newly diagnosed type 2 diabetes

• Published in: Diabetologia 2016-10, Vol.59 (10), p.2203-2207
• Main Authors: Apostolopoulou, Maria, Strassburger, Klaus, Herder, Christian, Knebel, Birgit, Kotzka, Jörg, Szendroedi, Julia, Roden, Michael
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Blood Glucose - metabolism; C-Reactive Protein - metabolism; Calorimetry, Indirect; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - metabolism; Exercise; Female; Flexibility; Glucose; Glucose Clamp Technique; Human Physiology; Humans; Hypotheses; Insulin - metabolism; Insulin resistance; Insulin Resistance - physiology; Internal Medicine; Kinases; Male; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolism; Middle Aged; Muscle, Skeletal - metabolism; Obesity - blood; Obesity - metabolism; Overweight - blood; Overweight - metabolism; Oxidation; Oxidation-Reduction; Oxygen Consumption - physiology; Physical fitness; Proteins; Short Communication; Young Adult
• ISSN: 0012-186X; 1432-0428
• DOI: 10.1007/s00125-016-4038-9

Aims/hypothesis Both inherited and acquired insulin resistance have been associated with abnormal muscle mitochondrial function. At whole-body level, maximal oxygen uptake ( V . O 2 max ) and/or metabolic flexibility (as given by ΔRQ) reflect certain features of mitochondrial function. This study tests the hypotheses (1) that V . O 2 max and ΔRQ correlate tightly with each other and with insulin sensitivity and (2) that glycaemia, lipidaemia or subclinical inflammation would explain such relationships. Methods Near-normoglycaemic individuals with type 2 diabetes mellitus ( n  = 136) with a short known disease duration (