Prognostic Significance of Solid and Micropapillary Components in Invasive Lung Adenocarcinomas Measuring ≤3 cm

We aimed to analyze the clinical impact of solid and micropapillary components in a series of Japanese patients resected for ≤3 cm lung adenocarcinoma. A total of 115 patients with ≤3 cm lung adenocarcinomas were reviewed and classified according to the American Thoracic Society and the European Res...

Full description

Saved in:
Bibliographic Details
Published in:Anticancer research 2016-09, Vol.36 (9), p.4923-4930
Main Authors: Matsuoka, Yuki, Yurugi, Yohei, Takagi, Yuzo, Wakahara, Makoto, Kubouchi, Yasuaki, Sakabe, Tomohiko, Haruki, Tomohiro, Araki, Kunio, Taniguchi, Yuji, Nakamura, Hiroshige, Umekita, Yoshihisa
Format: Article
Language:English
Subjects:
Adenocarcinoma - epidemiology
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Adenocarcinoma of Lung
Adenocarcinoma, Papillary - epidemiology
Adenocarcinoma, Papillary - pathology
Adenocarcinoma, Papillary - surgery
Adult
Aged
Disease-Free Survival
Female
Humans
Kaplan-Meier Estimate
Lung Neoplasms - epidemiology
Lung Neoplasms - pathology
Lung Neoplasms - surgery
Male
Middle Aged
Neoplasm Invasiveness - pathology
Neoplasm Recurrence, Local - epidemiology
Neoplasm Recurrence, Local - pathology
Neoplasm Staging
Prognosis
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We aimed to analyze the clinical impact of solid and micropapillary components in a series of Japanese patients resected for ≤3 cm lung adenocarcinoma. A total of 115 patients with ≤3 cm lung adenocarcinomas were reviewed and classified according to the American Thoracic Society and the European Respiratory Society classification. The presence of solid (S+) or micropapillary component (MP+) was defined when the component constituted ≥1% of the entire tumor. The impact of these components on disease-free (DFS) and disease-specific (DSS) survival was analyzed. Thirty (26.1%) cases with S+ and 27 (23.5%) with MP+ were identified, and multivariate analysis indicated that S+ status significantly reduced the duration of DFS and DSS. In 86 patients of acinar- and papillary-predominant subgroups, S+ and/or MP+ had the most significant effect on DFS and DSS by multivariate analysis. S+ and/or MP+ status predict worse prognosis in patients with acinar- and papillary-predominant lung adenocarcinoma.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.11058