Coenzyme Q10 – A new player in the treatment of heart failure?

Coenzyme Q10 is the only endogenously synthesized lipid with a redox function which exhibits broad tissue and intracellular distribution in mammals. Beneficial effects of Coenzyme Q10 supplementation were observed in several age-related diseases including heart failure. CoQ10 (coenzyme Q10) level is...

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Bibliographic Details
Published in:Pharmacological reports 2016-10, Vol.68 (5), p.1015-1019
Main Authors: Jankowski, Jerzy, Korzeniowska, Katarzyna, Cieślewicz, Artur, Jabłecka, Anna
Format: Article
Language:English
Subjects:
Animals
Clinical Trials as Topic
Coenzyme Q10
Dietary Supplements
Drug Safety and Pharmacovigilance
Heart failure
Heart Failure - drug therapy
Heart Failure - prevention & control
Humans
Pharmacotherapy
Pharmacy
Review Article
Supplementation
Ubiquinone - administration & dosage
Ubiquinone - analogs & derivatives
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Summary:Coenzyme Q10 is the only endogenously synthesized lipid with a redox function which exhibits broad tissue and intracellular distribution in mammals. Beneficial effects of Coenzyme Q10 supplementation were observed in several age-related diseases including heart failure. CoQ10 (coenzyme Q10) level is significantly decreased in patients with this disease, which correlates with severity of clinical symptoms. Supplementation with various pharmaceutical formulations of CoQ10 improves impaired cardiac function and clinical course of heart failure. Current data from clinical trials indicate that CoQ10 can significantly reduce morbidity and mortality of heart failure patients in addition to guideline recommended pharmacotherapy.
ISSN:1734-1140
2299-5684
DOI:10.1016/j.pharep.2016.05.012