Prenatal Exposure To Magnetic Field Increases Dopamine Levels In The Striatum Of Offspring

SUMMARY 1. The putative effects of prenatal exposure to magnetic field (MF) have recently received much interest. In the present study, mice were exposed to a MF of 50 mT during gestation (0–19 days). 2. After the exposure was terminated, mothers and offspring were returned to normal laboratory cond...

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Published in:Clinical and experimental pharmacology & physiology 2001-11, Vol.28 (11), p.884-886
Main Authors: Lee, Byung-Cheon, Bing, Guoying, Jhoo, Wang-Kee, Yoon, Joo-Mae, Kang, Kee-Seok, Shin, Eun-Joo, Kim, Won-Ki, Ko, Kwang Ho, Kim, Hyoung-Chun
Format: Article
Language:English
Subjects:
3,4-Dihydroxyphenylacetic Acid - metabolism
Animals
Corpus Striatum - embryology
Corpus Striatum - metabolism
dopamine
Dopamine - metabolism
Female
Fetus - metabolism
magnetic field
Magnetics - adverse effects
Mice
Mice, Inbred C57BL
perinatal effect
Pregnancy
Prenatal Exposure Delayed Effects
striatum
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Summary:SUMMARY 1. The putative effects of prenatal exposure to magnetic field (MF) have recently received much interest. In the present study, mice were exposed to a MF of 50 mT during gestation (0–19 days). 2. After the exposure was terminated, mothers and offspring were returned to normal laboratory conditions. We then determined changes in striatal levels of dopamine (DA) and its metabolite 3,4‐dihydroxyphenylacetic acid (DOPAC) in the offspring. 3. Our results indicate that prenatal exposure to MF increases levels of DA and DOPAC in the striatum at 4, 8 and 12 weeks postnatally.
ISSN:0305-1870
1440-1681
DOI:10.1046/j.1440-1681.2001.03538.x