The influence of rigid gas permeable lens wear on the concentrations of dinucleotides in tears and the effect on dry eye signs and symptoms in keratoconus

Highlights • Ap4 A, Ap5 A and dry eye symptoms increase in keratoconus vs. healthy subjects. • RGP wearing exacerbates the signs and symptoms of dry eye in keratoconus patients. • RGP lens wear increases the Ap4 A concentration in the tears of keratoconus patients.

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Bibliographic Details
Published in:Contact lens & anterior eye 2016-10, Vol.39 (5), p.375-379
Main Authors: Carracedo, Gonzalo, González-Méijome, José Manuel, Martín-Gil, Alba, Carballo, Jesús, Pintor, Jesús
Format: Article
Language:English
Subjects:
Adult
Biomarkers - analysis
Contact Lenses - adverse effects
Dinucleoside Phosphates - analysis
Dry eye
Dry Eye Syndromes - diagnosis
Dry Eye Syndromes - etiology
Dry Eye Syndromes - metabolism
Female
Gases - chemistry
GP lenses
Humans
Keratoconus
Keratoconus - complications
Keratoconus - metabolism
Keratoconus - therapy
Male
Middle Aged
Nucleotides
Ophthalmology
Permeability
Reproducibility of Results
Sensitivity and Specificity
Symptom Assessment
Tears - chemistry
Young Adult
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Description
Summary:Highlights • Ap4 A, Ap5 A and dry eye symptoms increase in keratoconus vs. healthy subjects. • RGP wearing exacerbates the signs and symptoms of dry eye in keratoconus patients. • RGP lens wear increases the Ap4 A concentration in the tears of keratoconus patients.
ISSN:1367-0484
1476-5411
DOI:10.1016/j.clae.2016.04.009