Local immune responses to influenza antigen are synergistically enhanced by the adjuvant ISCOMATRIX registered

The peripheral (draining) lymph node, as the primary site of immune induction, determines the course of systemic responses to an injected antigen. Lymphatic duct cannulation procedures in sheep were used to investigate local immunoreactivity to human influenza virus antigen (Flu ag) admixed with the...

Full description

Saved in:
Bibliographic Details
Published in:Vaccine 2001-11, Vol.20 (3-4), p.490-497
Main Authors: Windon, R G, Chaplin, P J, McWaters, P, Tavarnesi, M, Tzatzaris, M, Kimpton, W G, Cahill, RNP, Beezum, L, Coulter, A, Drane, D, Sjoelander, A, Pearse, M, Scheerlinck, J-PY, Tennent, J M
Format: Article
Language:English
Subjects:
Influenza virus
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 497
container_issue 3-4
container_start_page 490
container_title Vaccine
container_volume 20
creator Windon, R G
Chaplin, P J
McWaters, P
Tavarnesi, M
Tzatzaris, M
Kimpton, W G
Cahill, RNP
Beezum, L
Coulter, A
Drane, D
Sjoelander, A
Pearse, M
Scheerlinck, J-PY
Tennent, J M
description The peripheral (draining) lymph node, as the primary site of immune induction, determines the course of systemic responses to an injected antigen. Lymphatic duct cannulation procedures in sheep were used to investigate local immunoreactivity to human influenza virus antigen (Flu ag) admixed with the adjuvant ISCOMATRIX registered (IMX). Compared to Flu ag or IMX alone, the co-administration of Flu ag and IMX (Flu ag + IMX) synergistically enhanced a number of immunological responses (lymphocyte and blast migration from the node, antigen-specific antibody levels and IL6 output in efferent lymph, and antigen-induced proliferation in cultured efferent lymph cells). Together, these results demonstrate that IMX is an immune modulator, and that lymphatic duct cannulation procedures may be used to evaluate antigen/adjuvant combinations for vaccine development.
format article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_18220262</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>18220262</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_182202623</originalsourceid><addsrcrecordid>eNqNzs0KwjAQBOAcFPx9hz15E9JWRY8iioIiqAdvEtttjaQbzSZCfXor-ACe5jLfMA3RlvFkNBxF8twSHea7lHKcRLO2oK1NlQFdloEQHPLDEiODt6ApNwHprUCR1wUSKIfAFaErNHtdO1MB0k1RihlcK_A3BJXdw6sGsDku9rv56bA517NfgA6znmjmyjD2f9kVg9XytFgPH84-A7K_lJpTNEYR2sCXaBrH9fU4-bv4Af0zTQE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18220262</pqid></control><display><type>article</type><title>Local immune responses to influenza antigen are synergistically enhanced by the adjuvant ISCOMATRIX registered</title><source>ScienceDirect Journals</source><creator>Windon, R G ; Chaplin, P J ; McWaters, P ; Tavarnesi, M ; Tzatzaris, M ; Kimpton, W G ; Cahill, RNP ; Beezum, L ; Coulter, A ; Drane, D ; Sjoelander, A ; Pearse, M ; Scheerlinck, J-PY ; Tennent, J M</creator><creatorcontrib>Windon, R G ; Chaplin, P J ; McWaters, P ; Tavarnesi, M ; Tzatzaris, M ; Kimpton, W G ; Cahill, RNP ; Beezum, L ; Coulter, A ; Drane, D ; Sjoelander, A ; Pearse, M ; Scheerlinck, J-PY ; Tennent, J M</creatorcontrib><description>The peripheral (draining) lymph node, as the primary site of immune induction, determines the course of systemic responses to an injected antigen. Lymphatic duct cannulation procedures in sheep were used to investigate local immunoreactivity to human influenza virus antigen (Flu ag) admixed with the adjuvant ISCOMATRIX registered (IMX). Compared to Flu ag or IMX alone, the co-administration of Flu ag and IMX (Flu ag + IMX) synergistically enhanced a number of immunological responses (lymphocyte and blast migration from the node, antigen-specific antibody levels and IL6 output in efferent lymph, and antigen-induced proliferation in cultured efferent lymph cells). Together, these results demonstrate that IMX is an immune modulator, and that lymphatic duct cannulation procedures may be used to evaluate antigen/adjuvant combinations for vaccine development.</description><identifier>ISSN: 0264-410X</identifier><language>eng</language><subject>Influenza virus</subject><ispartof>Vaccine, 2001-11, Vol.20 (3-4), p.490-497</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Windon, R G</creatorcontrib><creatorcontrib>Chaplin, P J</creatorcontrib><creatorcontrib>McWaters, P</creatorcontrib><creatorcontrib>Tavarnesi, M</creatorcontrib><creatorcontrib>Tzatzaris, M</creatorcontrib><creatorcontrib>Kimpton, W G</creatorcontrib><creatorcontrib>Cahill, RNP</creatorcontrib><creatorcontrib>Beezum, L</creatorcontrib><creatorcontrib>Coulter, A</creatorcontrib><creatorcontrib>Drane, D</creatorcontrib><creatorcontrib>Sjoelander, A</creatorcontrib><creatorcontrib>Pearse, M</creatorcontrib><creatorcontrib>Scheerlinck, J-PY</creatorcontrib><creatorcontrib>Tennent, J M</creatorcontrib><title>Local immune responses to influenza antigen are synergistically enhanced by the adjuvant ISCOMATRIX registered</title><title>Vaccine</title><description>The peripheral (draining) lymph node, as the primary site of immune induction, determines the course of systemic responses to an injected antigen. Lymphatic duct cannulation procedures in sheep were used to investigate local immunoreactivity to human influenza virus antigen (Flu ag) admixed with the adjuvant ISCOMATRIX registered (IMX). Compared to Flu ag or IMX alone, the co-administration of Flu ag and IMX (Flu ag + IMX) synergistically enhanced a number of immunological responses (lymphocyte and blast migration from the node, antigen-specific antibody levels and IL6 output in efferent lymph, and antigen-induced proliferation in cultured efferent lymph cells). Together, these results demonstrate that IMX is an immune modulator, and that lymphatic duct cannulation procedures may be used to evaluate antigen/adjuvant combinations for vaccine development.</description><subject>Influenza virus</subject><issn>0264-410X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqNzs0KwjAQBOAcFPx9hz15E9JWRY8iioIiqAdvEtttjaQbzSZCfXor-ACe5jLfMA3RlvFkNBxF8twSHea7lHKcRLO2oK1NlQFdloEQHPLDEiODt6ApNwHprUCR1wUSKIfAFaErNHtdO1MB0k1RihlcK_A3BJXdw6sGsDku9rv56bA517NfgA6znmjmyjD2f9kVg9XytFgPH84-A7K_lJpTNEYR2sCXaBrH9fU4-bv4Af0zTQE</recordid><startdate>20011112</startdate><enddate>20011112</enddate><creator>Windon, R G</creator><creator>Chaplin, P J</creator><creator>McWaters, P</creator><creator>Tavarnesi, M</creator><creator>Tzatzaris, M</creator><creator>Kimpton, W G</creator><creator>Cahill, RNP</creator><creator>Beezum, L</creator><creator>Coulter, A</creator><creator>Drane, D</creator><creator>Sjoelander, A</creator><creator>Pearse, M</creator><creator>Scheerlinck, J-PY</creator><creator>Tennent, J M</creator><scope>7T5</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20011112</creationdate><title>Local immune responses to influenza antigen are synergistically enhanced by the adjuvant ISCOMATRIX registered</title><author>Windon, R G ; Chaplin, P J ; McWaters, P ; Tavarnesi, M ; Tzatzaris, M ; Kimpton, W G ; Cahill, RNP ; Beezum, L ; Coulter, A ; Drane, D ; Sjoelander, A ; Pearse, M ; Scheerlinck, J-PY ; Tennent, J M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_182202623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Influenza virus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Windon, R G</creatorcontrib><creatorcontrib>Chaplin, P J</creatorcontrib><creatorcontrib>McWaters, P</creatorcontrib><creatorcontrib>Tavarnesi, M</creatorcontrib><creatorcontrib>Tzatzaris, M</creatorcontrib><creatorcontrib>Kimpton, W G</creatorcontrib><creatorcontrib>Cahill, RNP</creatorcontrib><creatorcontrib>Beezum, L</creatorcontrib><creatorcontrib>Coulter, A</creatorcontrib><creatorcontrib>Drane, D</creatorcontrib><creatorcontrib>Sjoelander, A</creatorcontrib><creatorcontrib>Pearse, M</creatorcontrib><creatorcontrib>Scheerlinck, J-PY</creatorcontrib><creatorcontrib>Tennent, J M</creatorcontrib><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Windon, R G</au><au>Chaplin, P J</au><au>McWaters, P</au><au>Tavarnesi, M</au><au>Tzatzaris, M</au><au>Kimpton, W G</au><au>Cahill, RNP</au><au>Beezum, L</au><au>Coulter, A</au><au>Drane, D</au><au>Sjoelander, A</au><au>Pearse, M</au><au>Scheerlinck, J-PY</au><au>Tennent, J M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Local immune responses to influenza antigen are synergistically enhanced by the adjuvant ISCOMATRIX registered</atitle><jtitle>Vaccine</jtitle><date>2001-11-12</date><risdate>2001</risdate><volume>20</volume><issue>3-4</issue><spage>490</spage><epage>497</epage><pages>490-497</pages><issn>0264-410X</issn><abstract>The peripheral (draining) lymph node, as the primary site of immune induction, determines the course of systemic responses to an injected antigen. Lymphatic duct cannulation procedures in sheep were used to investigate local immunoreactivity to human influenza virus antigen (Flu ag) admixed with the adjuvant ISCOMATRIX registered (IMX). Compared to Flu ag or IMX alone, the co-administration of Flu ag and IMX (Flu ag + IMX) synergistically enhanced a number of immunological responses (lymphocyte and blast migration from the node, antigen-specific antibody levels and IL6 output in efferent lymph, and antigen-induced proliferation in cultured efferent lymph cells). Together, these results demonstrate that IMX is an immune modulator, and that lymphatic duct cannulation procedures may be used to evaluate antigen/adjuvant combinations for vaccine development.</abstract></addata></record>
fulltext fulltext
identifier ISSN: 0264-410X
ispartof Vaccine, 2001-11, Vol.20 (3-4), p.490-497
issn 0264-410X
language eng
recordid cdi_proquest_miscellaneous_18220262
source ScienceDirect Journals
subjects Influenza virus
title Local immune responses to influenza antigen are synergistically enhanced by the adjuvant ISCOMATRIX registered
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T12%3A00%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Local%20immune%20responses%20to%20influenza%20antigen%20are%20synergistically%20enhanced%20by%20the%20adjuvant%20ISCOMATRIX%20registered&rft.jtitle=Vaccine&rft.au=Windon,%20R%20G&rft.date=2001-11-12&rft.volume=20&rft.issue=3-4&rft.spage=490&rft.epage=497&rft.pages=490-497&rft.issn=0264-410X&rft_id=info:doi/&rft_dat=%3Cproquest%3E18220262%3C/proquest%3E%3Cgrp_id%3Ecdi_FETCH-proquest_miscellaneous_182202623%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=18220262&rft_id=info:pmid/&rfr_iscdi=true