Toxins of Bacillus anthracis

Bacillus anthracis, a gram positive bacterium, is the causative agent of anthrax. This organism is capsulogen and toxinogenic. It secretes two toxins which are composed of three proteins: the protective antigen (PA), the lethal factor (LF) and the edema factor (EF). The lethal toxin (PA+LF) provokes...

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Published in:Toxicon (Oxford) 2001-11, Vol.39 (11), p.1747-1755
Main Authors: Brossier, F, Mock, M
Format: Article
Language:English
Subjects:
Animals
Anthrax - pathology
Antigens, Bacterial
Bacillus anthracis
Bacillus anthracis - chemistry
Bacterial Toxins - chemistry
Bacterial Toxins - toxicity
Humans
Immunoprotection
Pathogenesis
Structure-Activity Relationship
Toxins
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description Bacillus anthracis, a gram positive bacterium, is the causative agent of anthrax. This organism is capsulogen and toxinogenic. It secretes two toxins which are composed of three proteins: the protective antigen (PA), the lethal factor (LF) and the edema factor (EF). The lethal toxin (PA+LF) provokes a subit death in animals, the edema toxin (PA+EF) induces edema. The edema and the lethal factors are internalised into the eukaryotic target cells via the protective antigen. EF and LF exert a calmoduline dependent adenylate cyclase and a metalloprotease activity respectively. Progress in the structure–function relationship of these three proteins, their regulation mechanisms and their roles in pathogenesis and immunoprotection will be exposed.
doi_str_mv 10.1016/S0041-0101(01)00161-1
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subjects Animals
Anthrax - pathology
Antigens, Bacterial
Bacillus anthracis
Bacillus anthracis - chemistry
Bacterial Toxins - chemistry
Bacterial Toxins - toxicity
Humans
Immunoprotection
Pathogenesis
Structure-Activity Relationship
Toxins
title Toxins of Bacillus anthracis
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