Pleiotropic Effects of Herbs Characterized with Blood-Activating and Stasis-Resolving Functions on Angiogenesis

• Published in: Chinese journal of integrative medicine 2016-10, Vol.22 (10), p.795-800
• Main Author: 陶丽 王生 赵杨 王爱云 张蕾 阮君山 范方田 刘玉萍 李尧 岳志强 钱文慧 陈文星 陆茵
• Format: Article
• Language: English
• Subjects: Angiogenesis Inhibitors - chemistry; Angiogenesis Inhibitors - therapeutic use; Animals; Antineoplastic Agents - therapeutic use; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - therapeutic use; Humans; Medicine; Medicine & Public Health; Models, Biological; Neovascularization, Pathologic - blood; Neovascularization, Pathologic - drug therapy; Review; 中药; 基础环; 多效性; 活血化瘀; 相互作用; 缺血性疾病; 肿瘤血管生成; 静止状态
• ISSN: 1672-0415; 1993-0402
• DOI: 10.1007/s11655-015-2405-x

Accumulative evidences have underpinned the nature candidates from Chinese medicine （CM）, particularly CM served as blood activating and stasis resolving （BASR, Huoxue Huayu in Chinese） by targeting tumor-associated angiogenesis. However, recent experiment research on the therapeutic angiogenesis by BASR-CM attracts wide attention and discussion. This opinion review focused on the underlying link between two indications and anticipated that （1） BASR-CM might emphasize on a balanced multi-cytokines network interaction; （2） BASR-CM might address on the nature of diseases prior to differently affecting physiological and pathological angiogenesis; （3） BASR-CM might mainly act on perivascular cells, either promotes arteriogenesis by increasing arteriogenic factors in ischemic diseases, or simultaneously keep a quiescent vasculature to impede angiogenesis in tumor context.