Estrogen-estrogen receptor signaling suppresses the transcription of ERRF in breast cancer cells

The estrogen receptor （ER）-related factor （ERRF） was previously reported as a novel modulator of breast cancer （Suet al., 2012）. Its expression was upregulated in breast cancer, and increased ERRF expression was significantly associated with ER and/or progesterone receptor （PR） positivity and human...

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Bibliographic Details
Published in:Journal of genetics and genomics 2016-09, Vol.43 (9), p.565-567
Main Authors: Luo, Ang, Su, Dan, Zhang, Xuan, Qi, Leilei, Fu, Liya, Dong, Jin-Tang
Format: Article
Language:English
Subjects:
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cell Line, Tumor
Cell Proliferation
Down-Regulation
Estrogens - metabolism
Humans
Nuclear Proteins - genetics
Receptors, Estrogen - metabolism
Signal Transduction - genetics
Transcription, Genetic
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Summary:The estrogen receptor （ER）-related factor （ERRF） was previously reported as a novel modulator of breast cancer （Suet al., 2012）. Its expression was upregulated in breast cancer, and increased ERRF expression was significantly associated with ER and/or progesterone receptor （PR） positivity and human epidermal growth factor receptor 2 （HER2） negativity （Suet al., 2012）. In addition, ERRF was necessary for ER-positive breast cancer cells to form tumors in nude mice （Suet al., 2012）. Unexpectedly,
ISSN:1673-8527
DOI:10.1016/j.jgg.2016.06.003