SIPA1L2 , MIR4697 , GCH1 and VPS13C loci and risk of Parkinson's diseases in Iranian population: A case-control study

Abstract Parkinson ' s disease (PD) is the second most common neurodegenerative disorder. Prevalence of PD increases steadily with age. A recent meta-analysis of genome-wide association studies has identified six new loci to be linked with PD. Here we investigated the association of four of the...

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Bibliographic Details
Published in:Journal of the neurological sciences 2016-10, Vol.369, p.1-4
Main Authors: Safaralizadeh, Tannaz, Jamshidi, Javad, Shandiz, Ehsan Esmaili, Movafagh, Abolfazl, Fazeli, Atena, Emamalizadeh, Babak, Manafi, Navid, Taghavi, Shaghayegh, Tafakhori, Abbas, Darvish, Hossein
Format: Article
Language:English
Subjects:
Adult
Aged
Case-Control Studies
Female
GCH1
Gene Frequency
Genetic Predisposition to Disease - genetics
Genome-Wide Association Study
Genotype
GTP Cyclohydrolase - genetics
GTPase-Activating Proteins - genetics
Humans
Iran
Iranian population
Male
MicroRNAs - genetics
Middle Aged
MIR4697
Neurology
Nuclear Proteins - genetics
Parkinson Disease - genetics
Parkinson's disease
Polymorphism
Polymorphism, Single Nucleotide - genetics
Proteins - genetics
VPS13C
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Summary:Abstract Parkinson ' s disease (PD) is the second most common neurodegenerative disorder. Prevalence of PD increases steadily with age. A recent meta-analysis of genome-wide association studies has identified six new loci to be linked with PD. Here we investigated the association of four of these new loci, SIPA1L2 , MIR4697 , GCH1 and VPS13C with PD in an Iranian population. Through a case-control study a total of 1800 subjects comprising 600 PD patients and 1200 unrelated healthy controls were recruited. Rs10797576, rs329648, rs11158026 and rs2414739 related to SIPA1L2, MIR4697, GCH1 and VPS13C loci respectively, were genotyped in all subjects. The difference of genotype and allele frequencies between case and control groups were investigated using chi-square test and logistic regression models with R software. Genotype and allele frequencies were significantly different in PD patients and control group for rs329648, rs11158026 and rs2414739 ( p -value = 0.018, 0.025, and 0.009 respectively for allele frequency differences). There was no difference in genotype nor allele frequencies between the two groups for rs10797576. We replicated the association of three new loci which are proposed for PD. More studies in other populations and also functional analysis are required to clear the role of these variants in PD.
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2016.08.001