The effect of ionized collagen for preventing postoperative adhesion

• Published in: The Journal of surgical research 2016-10, Vol.205 (2), p.341-349
• Main Authors: Chung, Young Soo, MD, PhD, Park, Si-Nae, PhD, Ko, Jae Hyung, MS, Bae, Sang Hee, MS, Lee, Song, PhD, Shim, In Kyong, PhD, Kim, Song Cheol, MD, PhD
• Format: Article
• Language: English
• Subjects: Animals; Antiadhesive materials; Biocompatible Materials - therapeutic use; Carboxymethylcellulose Sodium - therapeutic use; Cecum - surgery; Cellulose, Oxidized - therapeutic use; Collagen; Collagen - therapeutic use; Esterification; Hyaluronic Acid - therapeutic use; Incidence; Male; Postoperative adhesion; Postoperative Complications - epidemiology; Postoperative Complications - prevention & control; Random Allocation; Rats; Rats, Sprague-Dawley; Surgery; Tissue Adhesions - epidemiology; Tissue Adhesions - etiology; Tissue Adhesions - prevention & control; Treatment Outcome
• ISSN: 0022-4804; 1095-8673
• DOI: 10.1016/j.jss.2016.06.095

Abstract Background Collagen exhibits ideal multifactorial action for preventing tissue adhesions. This study examined the efficacy of ionized collagen in preventing tissue adhesion after surgical procedures. Materials and method Ionized collagen was prepared using the esterification technique of natural collagen. Three forms of collagen materials (membrane, film, and gel) were compared with three commercialized materials (oxidized regenerated cellulose membrane (OC membrane), hyaluronic acid and carboxymethylcellulose film, and gel (HC film and HC gel))in a rat cecum abrasion model. Anti-adhesive activity and histological findings were assessed. Result The incidence of adhesion was reduced significantly in all test groups compared to the sham-operated control group (100% in control, 14.3% in collagen membrane, 63.6% in collagen film, 25.0% in collagen gel, 55.6% in OC membrane, 75% in HC film and 83.3% in HC gel). All collagen materials of the three forms exhibited a significant reduction in adhesion grade compared with the sham operation, while no significant difference was found among these three different forms. The collagen membrane showed significantly less adhesion grade, less inflammation and more regenerative features compared to widely used conventional materials. Conclusion This preclinical investigation indicated that ionized collagen materials readily formed clinically suitable shapes for easy handling without the need for any complex processing and effectively reduced postoperative tissue adhesion profiles compared to conventional anti-adhesive agents.