Nanoscale powders and formulations with biocidal activity toward spores and vegetative cells of Bacillus species, viruses, and toxins

Certain formulations of nanoscale powders possess antimicrobial properties. These formulations are made of simple, nontoxic metal oxides such as magnesium oxide (MgO) and calcium oxide (CaO, lime) in nanocrystalline form, carrying active forms of halogens, for example, MgO. Cl2 and MgO. Br2. When th...

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Bibliographic Details
Published in:Current microbiology 2002, Vol.44 (1), p.49-55
Main Authors: KOPER, Olga B, KLABUNDE, John S, MARCHIN, George L, KLABUNDE, Kenneth J, STOIMENOV, Peter, BOHRA, Lalit
Format: Article
Language:English
Subjects:
Action of physical and chemical agents on bacteria
Aflatoxins
Aflatoxins - pharmacology
Animals
Bacillus
Bacillus - drug effects
Bacillus cereus
Bacteriology
Biological and medical sciences
Calcium Compounds - pharmacology
calcium oxide
Colony Count, Microbial
Decontamination
Disinfectants - pharmacology
Dose-Response Relationship, Drug
E coli
Escherichia coli - drug effects
Fundamental and applied biological sciences. Psychology
Halogens
Halogens - pharmacology
Levivirus - drug effects
Magnesium
magnesium oxide
Magnesium Oxide - pharmacology
Microbiology
Nanotechnology
Oxides - pharmacology
Particle Size
Phage MS2
Powders
Spores - drug effects
Toxins
Toxins, Biological
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Summary:Certain formulations of nanoscale powders possess antimicrobial properties. These formulations are made of simple, nontoxic metal oxides such as magnesium oxide (MgO) and calcium oxide (CaO, lime) in nanocrystalline form, carrying active forms of halogens, for example, MgO. Cl2 and MgO. Br2. When these ultrafine powders contact vegetative cells of Escherichia coli, Bacillus cereus, or Bacillus globigii, over 90% are killed within a few minutes. Likewise, spore forms of the Bacillus species are decontaminated within several hours. Dry contact with aflatoxins and contact with MS2 bacteriophage (surrogate of human enterovirus) in water also causes decontamination in minutes.
ISSN:0343-8651
1432-0991
DOI:10.1007/s00284-001-0073-x