Impact of Malondialdehyde-Modified Low-Density Lipoprotein on Tissue Characteristics in Patients With Stable Coronary Artery Disease　– Integrated Backscatter-Intravascular Ultrasound Study

Background:Malondialdehyde-modified low-density lipoprotein (MDA-LDL) is considered to play an essential role in plaque destabilization. We aimed to investigate the association between the tissue characteristics of culprit plaque assessed by integrated backscatter (IB)-intravascular ultrasound (IVUS...

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Published in:Circulation Journal 2016/09/23, Vol.80(10), pp.2173-2182
Main Authors: Ikenaga, Hiroki, Kurisu, Satoshi, Kono, Shingo, Sumimoto, Yoji, Watanabe, Noriaki, Shimonaga, Takashi, Higaki, Tadanao, Iwasaki, Toshitaka, Mitsuba, Naoya, Ishibashi, Ken, Dohi, Yoshihiro, Fukuda, Yukihiro, Kihara, Yasuki
Format: Article
Language:English
Subjects:
Aged
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - metabolism
Coronary plaque vulnerability
Female
Humans
Integrated backscatter-intravascular ultrasound
Lipoproteins, LDL - metabolism
Male
Malondialdehyde - metabolism
Malondialdehyde-modified low-density lipoprotein
Middle Aged
Retrospective Studies
Ultrasonography, Interventional
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Summary:Background:Malondialdehyde-modified low-density lipoprotein (MDA-LDL) is considered to play an essential role in plaque destabilization. We aimed to investigate the association between the tissue characteristics of culprit plaque assessed by integrated backscatter (IB)-intravascular ultrasound (IVUS) and the serum MDA-LDL levels in patients with stable coronary artery disease.Methods and Results:The study group consisted of 179 patients undergoing IB-IVUS during elective percutaneous coronary intervention. Patients were classified into 2 groups based on serum MDA-LDL level: low MDA-LDL group (
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-16-0451