Action of secondary ions on biomolecules: anisotropy and radio-sensitization properties

The charge transfer process of carbon ions on biomolecular targets is analyzed with regard to the action of radiation on the biological medium. The theoretical treatment is performed in a wide collision energy range by means of ab-initio quantum chemistry molecular methods. The process has been inve...

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Bibliographic Details
Published in:Journal of physics. Conference series 2012-01, Vol.373 (1), p.1-8
Main Author: Bacchus-Montabonel, M C
Format: Article
Language:English
Subjects:
Anisotropy
Biomolecules
Carbon
Charge transfer
Physics
Quantum chemistry
Radiation
Radiation damage
Thymine
Uracil
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Summary:The charge transfer process of carbon ions on biomolecular targets is analyzed with regard to the action of radiation on the biological medium. The theoretical treatment is performed in a wide collision energy range by means of ab-initio quantum chemistry molecular methods. The process has been investigated for a series of target molecules, thymine, uracil and 5-halouracil corresponding to a similar skeleton with different substituent. The charge transfer appears markedly anisotropic in the whole energy domain, and interesting specific features may be pointed out at low energies. In addition, such a study may provide information on the radio-sensitivity of the different bases with regard to ion-induced radiation damage.
ISSN:1742-6596
1742-6588
1742-6596
DOI:10.1088/1742-6596/373/1/012002