Ionization of biomolecular targets by ion impact: input data for radiobiological applications

In this work we review and further develop a semiempirical model recently proposed for the ion impact ionization of complex biological media. The model is based on the dielectric formalism, and makes use of a semiempirical parametrization of the optical energy-loss function of bioorganic compounds,...

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Bibliographic Details
Published in:Journal of physics. Conference series 2013-01, Vol.438 (1), p.1-10
Main Authors: de Vera, Pablo, Abril, Isabel, Garcia-Molina, Rafael, Solov'yov, Andrey V
Format: Article
Language:English
Subjects:
Adenine
Adenines
Biological
Carbohydrates
Ion impact
Ionization
Ionization cross sections
Kinetic energy
Lipids
Mathematical models
Parameterization
Parametrization
Physics
Uracil
Water
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Summary:In this work we review and further develop a semiempirical model recently proposed for the ion impact ionization of complex biological media. The model is based on the dielectric formalism, and makes use of a semiempirical parametrization of the optical energy-loss function of bioorganic compounds, allowing the calculation of single and total ionization cross sections and related quantities for condensed biological targets, such as liquid water, DNA and its components, proteins, lipids, carbohydrates or cell constituents. The model shows a very good agreement with experimental data for water, adenine and uracil, and allows the comparison of the ionization efficiency of different biological targets, and also the average kinetic energy of the ejected secondary electrons.
ISSN:1742-6596
1742-6588
1742-6596
DOI:10.1088/1742-6596/438/1/012015