The Use of Calcium Channel Blockers in the Treatment of Coronary Spasm and Atrioventricular Block

Calcium channel blockers have been used in the treatment of coronary artery spasm for many years. However, there is insufficient knowledge about their application to treat atrioventricular block caused by coronary spasm. Clinical data of five patients who were diagnosed with coronary spasm caused by...

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Bibliographic Details
Published in:Cell biochemistry and biophysics 2015-06, Vol.72 (2), p.527-531
Main Authors: Gao, Bo, Zhang, Zhenjian, Qian, Jin, Cao, Chuanbin, Hua, Xianping, Chu, Mengting, HE, Xingwei, Zeng, Hesong
Format: Article
Language:English
Subjects:
Atrioventricular Block - diagnostic imaging
Atrioventricular Block - drug therapy
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biotechnology
Calcium Channel Blockers - administration & dosage
Calcium Channel Blockers - adverse effects
Calcium Channel Blockers - therapeutic use
Calcium channels
Cardiovascular Agents - administration & dosage
Cardiovascular Agents - adverse effects
Cardiovascular Agents - therapeutic use
Cell Biology
Coronary Angiography
Coronary Vasospasm - diagnostic imaging
Coronary Vasospasm - drug therapy
Diltiazem - administration & dosage
Diltiazem - adverse effects
Diltiazem - therapeutic use
Female
Humans
Life Sciences
Male
Middle Aged
Original Paper
Pharmacology/Toxicology
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Summary:Calcium channel blockers have been used in the treatment of coronary artery spasm for many years. However, there is insufficient knowledge about their application to treat atrioventricular block caused by coronary spasm. Clinical data of five patients who were diagnosed with coronary spasm caused by atrioventricular block and treated with calcium channel blockers were retrospectively assessed. The patients had varying degrees of atrioventricular block (confirmed by Holter ECG) and myocardial ischemia-like ST–T changes. Two patients were II type I AVB, two patients II type II AVB, and the remaining one patient was III AVB. All patients were all diagnosed with right coronary artery spasm by coronary angiography. The patients were treated with calcium channel blockers. No patient reported recurrence of chest pain or chest discomfort. On Holter ECG monitoring, no significant myocardial ischemia or atrioventricular block was seen. In conclusion, calcium channel blockers are effective and safe in the treatment of atrioventricular block caused by coronary spasm.
ISSN:1085-9195
1559-0283
DOI:10.1007/s12013-014-0498-z