Case Report. Successful outcome of invasive nasal sinus zygomycosis in a child with relapsed acute lymphoblastic leukaemia due to liposomal amphotericin B

We report a case of life‐threatening nasal sinus zygomycosis that developed during remission induction therapy for a relapsed acute lymphoblastic leukaemia. The patient was successfully treated with liposomal amphotericin B and granulocyte‐colony stimulating factor followed by surgical reconstructio...

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Bibliographic Details
Published in:Mycoses 2001-07, Vol.44 (5), p.195-199
Main Authors: Wali, Y. A., Al Lamki, Z., Al Kindi, H., Taqi, A. M., Shah, W., Soliman, H., Zackaria, M., Al Okbi, H.
Format: Article
Language:English
Subjects:
Absidia
Absidia corymbifera
amphotericin B
Amphotericin B - therapeutic use
Antifungal Agents - therapeutic use
Child
Dermatomycoses - complications
Dermatomycoses - drug therapy
Humans
Kind
leukaemia
Leukämie
liposomal formulation
liposomale Formulierung
Male
Mucormycosis - complications
Mucormycosis - drug therapy
nasal sinus infection
Nasennebenhöhlen-Infektion
Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications
Sinusitis - complications
Sinusitis - drug therapy
Tomography, X-Ray Computed
zygomycosis
Zygomykose
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Summary:We report a case of life‐threatening nasal sinus zygomycosis that developed during remission induction therapy for a relapsed acute lymphoblastic leukaemia. The patient was successfully treated with liposomal amphotericin B and granulocyte‐colony stimulating factor followed by surgical reconstruction of the resultant cutaneous defect. Zusammenfassung.  Es wird über den Fall einer lebensbedrohlichen Nasennebenhöhlen‐Zygomykose bei einem Kind während der Interventionstherapie bei akuter lymphatischer Leukämie berichtet. Der Junge wurde erfolgreich mit liposomalem Amphotericin B und Granulozyten‐Koloniestimulierendem Faktor (G‐CSF) behandelt. Der resultierende Hautdefekt wurde chirurgisch rekonstruiert.
ISSN:0933-7407
1439-0507
DOI:10.1046/j.1439-0507.2001.00610.x