Synergy and antagonism between iron chelators and antifungal drugs in cryptococcus

Highlights • Iron chelators were tested for synergy with antifungal drugs against Cryptococcus • Interactions between chelators and antifungals were uncommon. • Lactoferrin was synergistic with amphotericin B for all strains of Cryptococcus. • Azole drugs were antagonised by some chelators in Crypto...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2016-10, Vol.48 (4), p.388-394
Main Authors: Lai, Yu-Wen, Campbell, Leona T, Wilkins, Marc R, Pang, Chi Nam Ignatius, Chen, Sharon, Carter, Dee A
Format: Article
Language:English
Subjects:
Amphotericin B
Antifungal Agents - pharmacology
Antifungal drug synergy
Cryptococcus
Cryptococcus - drug effects
Drug Interactions
Infectious Disease
Iron Chelating Agents - pharmacology
Lactoferrin
Metal ion homeostasis
Microbial Sensitivity Tests
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Summary:Highlights • Iron chelators were tested for synergy with antifungal drugs against Cryptococcus • Interactions between chelators and antifungals were uncommon. • Lactoferrin was synergistic with amphotericin B for all strains of Cryptococcus. • Azole drugs were antagonised by some chelators in Cryptococcus neoformans var. grubii.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2016.06.012