Diabetes mellitus associated with olanzapine use

Atypical antipsychotics are widely used in psychotic disorders, refractory to conventional neuroleptic agents. They induce minimal extra pyramidal side effects, probably due to their greater affinity for certain dopaminergic receptors. However, this polyreceptor affinity may be responsible for the d...

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Bibliographic Details
Published in:Revista medíca de Chile 2001-10, Vol.129 (10), p.1183-1185
Main Authors: Rojas, P G, Arancibia, P S, Bravo, V S, Varela, S G
Format: Article
Language:Spanish
Subjects:
diabetes mellitus
neuroleptics
olanzapine
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Summary:Atypical antipsychotics are widely used in psychotic disorders, refractory to conventional neuroleptic agents. They induce minimal extra pyramidal side effects, probably due to their greater affinity for certain dopaminergic receptors. However, this polyreceptor affinity may be responsible for the development of other side effects. We report a 48 years old male drinker and addicted to cocaine, that after two months of Olanzapine use, developed a severe diabetes mellitus with fasting blood glucose values reaching 514 mg/dl. When he was admitted to the hospital, physical examination was normal and his body mass index was 28 kg/m super(2). Olanzapine was discontinued and blood glucose values gradually returned to normal. After two months of follow up, the patient is on dietary treatment and with a fasting glucose of 132 mg/dl
ISSN:0034-9887