Management strategies in patients with statin-associated muscle symptoms: What is the best strategy?

Highlights • Statin-associated muscle symptoms (SAMS) are commonly encountered. • Strategies are rechallenge, switch, nondaily statin dosing, or nonstatins. • Tolerability of each of these strategies is over 60%; efficacy is variable. • Several limitations are still encountered in the management of...

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Bibliographic Details
Published in:Journal of clinical lipidology 2016-09, Vol.10 (5), p.1067-1072
Main Authors: Joy, Tisha R., MD, FRCPC, FACE, Brennan, Emily T., MD, FRCPC
Format: Article
Language:English
Subjects:
Cardiovascular
Dose-Response Relationship, Drug
Drug Substitution - methods
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects
Lipid Metabolism - drug effects
Medication Therapy Management
Muscular Diseases - etiology
Muscular Diseases - prevention & control
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Summary:Highlights • Statin-associated muscle symptoms (SAMS) are commonly encountered. • Strategies are rechallenge, switch, nondaily statin dosing, or nonstatins. • Tolerability of each of these strategies is over 60%; efficacy is variable. • Several limitations are still encountered in the management of patients with SAMS. • Ultimately, patient involvement determines which strategy is most acceptable.
ISSN:1933-2874
1876-4789
DOI:10.1016/j.jacl.2016.06.008