Pathologic Findings of the Cochlea in Labyrinthitis Ossificans Associated with the Round Window Membrane

• Published in: Otolaryngology-head and neck surgery 2016-10, Vol.155 (4), p.635-640
• Main Authors: Kaya, Serdar, Paparella, Michael M., Cureoglu, Sebahattin
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Cadaver; Child; Child, Preschool; cochlea; Cochlea - pathology; cochlear implant; endolymphatic hydrops; Female; Hair Cells, Auditory - pathology; histopathology; human temporal bone; Humans; inner hair cell; Labyrinthitis - pathology; labyrinthitis ossificans; Male; Middle Aged; Minnesota; outer hair cell; round window membrane; Round Window, Ear - pathology; Spiral Ganglion - pathology; spiral ganglion cell; spiral ligament; stria vascularis; Stria Vascularis - pathology; Temporal Bone - pathology
• ISSN: 0194-5998; 1097-6817
• DOI: 10.1177/0194599816651245

Objective To quantitatively demonstrate and classify the histopathologic changes in the cochlea of the human temporal bones with labyrinthitis ossificans (LO). Study Design Comparative human temporal bone study. Setting Tertiary academic medical center. Subjects and Methods We compared 23 temporal bone specimens from 19 deceased donors with LO associated with the round window membrane (RWM) and 27 age-matched specimens from 20 deceased donors without any otologic diseases. We focused on the location of LO in the inner ear, the intensity of endolymphatic hydrops, the number of spiral ganglion cells and cochlear hair cells, and the areas of the stria vascularis and spiral ligament. In addition, we created a new pathologic grading system for temporal bone specimens from deceased donors with LO associated with the RWM. Results We most often observed LO in the scala tympani of the basal cochlear turn. In the LO group (as compared with the control group), the intensity of endolymphatic hydrops was significantly increased; the number of spiral ganglion cells was significantly decreased in all segments; the loss of outer and inner hair cells was significantly increased in all turns of the cochlea; the atrophy of the stria vascularis was significantly greater in all turns of the cochlea; and atrophy of the spiral ligament was significantly greater in the basal and middle cochlear turn. Conclusion LO was associated with significant cochlear damage (to the spiral ganglion cells, cochlear hair cells, stria vascularis, and spiral ligament) and with increased intensity of endolymphatic hydrops.