CRISPR-Cas9 System: Opportunities and Concerns

[...]if one could restore the wildtype allele coding for the cystic fibrosis transmembrane conductance regulator protein in a small percentage of lung epithelial cells of individuals afflicted with cystic fibrosis, a pronounced benefit for their lung functions would be expected. Fortunately, the 2 a...

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Published in:Clinical chemistry (Baltimore, Md.) Md.), 2016-10, Vol.62 (10), p.1304-1311
Main Authors: Vasiliou, Stella K, Diamandis, Eleftherios P, Church, George M, Greely, Henry T, Baylis, Françoise, Thompson, Charis, Schmitt-Ulms, Gerold
Format: Article
Language:English
Subjects:
Animals
Biomedical Research - legislation & jurisprudence
Biomedical Research - methods
Clustered Regularly Interspaced Short Palindromic Repeats - genetics
CRISPR-Cas Systems - genetics
Cystic fibrosis
Editing
Ethics
Gene Editing - legislation & jurisprudence
Gene Editing - methods
Genes
Genomes
Humans
Intellectual Property
Laboratories
Respiratory function
Science
Stem cells
Citations: Items that cite this one
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Summary:[...]if one could restore the wildtype allele coding for the cystic fibrosis transmembrane conductance regulator protein in a small percentage of lung epithelial cells of individuals afflicted with cystic fibrosis, a pronounced benefit for their lung functions would be expected. Fortunately, the 2 areas in which this technology may have the most pronounced impact, (i) its ability to greatly accelerate our understanding of the biological world around us, including how to diagnose and treat diseases, and (ii) the possibility it offers for subtly changing our environment to disarm pathogens or the vectors that transmit them, are of such a nature that they may eventually benefit all. [...]compared to the challenges posed by the potential abuse of this technology, unequal opportunities to access this technology for specific personalized medical applications may be a relatively small concern.
ISSN:0009-9147
1530-8561
DOI:10.1373/clinchem.2016.263186