Postexposure Prophylaxis for Human Immunodeficiency Virus Infection after Sexual or Injection Drug Use Exposure: Identification and Characterization of the Source of Exposure

In a nonrandomized study of nonoccupational postexposure prophylaxis (PEP), a cross-sectional evaluation of subjects who were the source of human immunodeficiency (HIV) exposure was performed to characterize partners of index subjects seeking nonoccupational PEP against HIV. Among 401 index subjects...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 2001-12, Vol.184 (12), p.1608-1612
Main Authors: Roland, Michelle E., Martin, Jeffrey N., Grant, Robert M., Hellmann, Nicholas S., Bamberger, Joshua D., Katz, Mitchell H., Chesney, Margaret, Franses, Karena, Coates, Thomas J., Kahn, James O.
Format: Article
Language:English
Subjects:
Adult
AIDS
Anti-HIV Agents - pharmacology
Anti-HIV Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antibodies
Antiretrovirals
Antivirals
Biological and medical sciences
Concise Communication
Contact Tracing
Cross-Sectional Studies
Drug Resistance, Viral - genetics
Female
HIV
HIV 1
HIV Antibodies - blood
HIV Infections - drug therapy
HIV Infections - prevention & control
HIV Infections - transmission
HIV-1 - genetics
HIV-1 - immunology
Human immunodeficiency virus
Human viral diseases
Humans
Infectious diseases
Male
Medical sciences
Medications
Pharmacology. Drug treatments
Post exposure prophylaxis
RNA
RNA, Viral - blood
Sexual Behavior
Subject indexing
Substance Abuse, Intravenous
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In a nonrandomized study of nonoccupational postexposure prophylaxis (PEP), a cross-sectional evaluation of subjects who were the source of human immunodeficiency (HIV) exposure was performed to characterize partners of index subjects seeking nonoccupational PEP against HIV. Among 401 index subjects, 64 (16%) recruited a source subject. Those in a steady relationship and those who knew that the source subject was HIV antibody positive were more likely to recruit their source subject. Source subjects reported high rates of past (78%) and current (69%) antiretroviral use; 46% of those using antiretroviral drugs had detectable plasma HIV-1 RNA levels. Antiretroviral resistance was detected in many source subjects who reported any use of antiretrovirals and was rare among source subjects who reported no history of antiretroviral use. Clinicians often make treatment decisions on the basis of incomplete knowledge of the source subject’s HIV status or antiretroviral treatment history. The treatment history, particularly nonuse of a class of antiretroviral drugs, can be used to predict drug resistance
ISSN:0022-1899
1537-6613
DOI:10.1086/324580