A multi-channel clogging-resistant lab-on-a-chip cell counter and analyzer

Early signs of diseases can be revealed from cell detection in biofluids, such as detection of white blood cells (WBCs) in the peritoneal fluid for peritonitis. A lab-on-a-chip microfluidic device offers an attractive platform for such applications because of its small size, low cost, and ease of us...

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Bibliographic Details
Published in:Journal of micromechanics and microengineering 2016-02, Vol.26 (2), p.25007-25014
Main Authors: Dai, Jie, Chiu, Yu-Jui, Lian, Ian, Wu, Tsung-Feng, Yang, Kecheng, Lo, Yu-Hwa
Format: Article
Language:English
Subjects:
Counting
Devices
Diseases
Fluid flow
Fluids
high flow rate
Microfluidics
non-clogging
peritoneal test
Plugging
WBC counter
White blood cells
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Summary:Early signs of diseases can be revealed from cell detection in biofluids, such as detection of white blood cells (WBCs) in the peritoneal fluid for peritonitis. A lab-on-a-chip microfluidic device offers an attractive platform for such applications because of its small size, low cost, and ease of use provided the device can meet the performance requirements which many existing LoC devices fail to satisfy. We report an integrated microfluidic device capable of accurately counting low concentration of white blood cells in peritoneal fluid at 150 μl min−1 to offer an accurate (
ISSN:0960-1317
1361-6439
DOI:10.1088/0960-1317/26/2/025007