Rod-shaped and fluorine-substituted hydroxyapatite free of molecular immunopotentiators stimulates anti-cancer immunity in vivo

Herein, rod-shaped and fluorine-substituted hydroxyapatite nanoparticles (FHA) were synthesized using a facile hydrothermal method. The rod-shaped FHA significantly increased the cellular uptake of a model antigen by bone marrow dentritic cells in vitro, improved antigen presentation in vivo, stimul...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (44), p.7078-7081
Main Authors: Wang, Xiupeng, Li, Xia, Ito, Atsuo, Watanabe, Yohei, Tsuji, Noriko M
Format: Article
Language:English
Subjects:
Antigens
Biomedical materials
Hydroxyapatite
Immunity
Nanoparticles
Secretions
Surgical implants
Uptakes
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Summary:Herein, rod-shaped and fluorine-substituted hydroxyapatite nanoparticles (FHA) were synthesized using a facile hydrothermal method. The rod-shaped FHA significantly increased the cellular uptake of a model antigen by bone marrow dentritic cells in vitro, improved antigen presentation in vivo, stimulated immune-related cytokine secretion in vitro and ex vivo, and enhanced the anti-cancer immunity in vivo.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc02848a