Combination of photothermal and photodynamic inactivation of cancer cells through surface plasmon resonance of a gold nanoring

We demonstrate effective inactivation of oral cancer cells SAS through a combination of photothermal therapy (PTT) and photodynamic therapy (PDT) effects based on localized surface plasmon resonance (LSPR) around 1064 nm in wavelength of a Au nanoring (NRI) under femtosecond (fs) laser illumination....

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Bibliographic Details
Published in:Nanotechnology 2016-03, Vol.27 (11), p.115102-115102
Main Authors: Chu, Chih-Ken, Tu, Yi-Chou, Hsiao, Jen-Hung, Yu, Jian-He, Yu, Chih-Kang, Chen, Shih-Yang, Tseng, Po-Hao, Chen, Shuai, Kiang, Yean-Woei, Yang, C C
Format: Article
Language:English
Subjects:
Cancer
cancer cell inactivation
Cell Line, Tumor
Cell Survival - drug effects
Gold
Gold - chemistry
gold nanoring
Humans
Hyperthermia, Induced
Illumination
Inactivation
Indoles - chemistry
Indoles - pharmacology
Lasers
localized surface plasmon resonance
Metal Nanoparticles
Mouth Neoplasms - therapy
Nanostructure
Nanotechnology
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Photochemotherapy
photodynamic therapy
Photosensitizing Agents - chemistry
Photosensitizing Agents - pharmacology
photothermal therapy
Surface Plasmon Resonance
Thresholds
two-photon absorption
Wavelengths
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Summary:We demonstrate effective inactivation of oral cancer cells SAS through a combination of photothermal therapy (PTT) and photodynamic therapy (PDT) effects based on localized surface plasmon resonance (LSPR) around 1064 nm in wavelength of a Au nanoring (NRI) under femtosecond (fs) laser illumination. The PTT effect is caused by the LSPR-enhanced absorption of the Au NRI. The PDT effect is generated by linking the Au NRI with the photosensitizer of sulfonated aluminum phthalocyanines (AlPcS) for producing singlet oxygen through the LSPR-enhanced two-photon absorption (TPA) excitation of AlPcS. The laser threshold intensity for cancer cell inactivation with the applied Au NRI linked with AlPcS is significantly lower when compared to that with the Au NRI not linked with AlPcS. The comparison of inactivation threshold intensity between the cases of fs and continuous laser illuminations at the same wavelength and with the same average power confirms the crucial factor of TPA under fs laser illumination for producing the PDT effect.
ISSN:0957-4484
1361-6528
DOI:10.1088/0957-4484/27/11/115102